Differentiating Parkinson's disease from multiple system atrophy by [123I] meta-iodobenzylguanidine myocardial scintigraphy and olfactory test

Akio Kikuchi, Toru Baba, Takafumi Hasegawa, Naoto Sugeno, Masatoshi Konno, Atsushi Takeda

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

We aimed to study whether either [ 123l] myocardial meta-iodobenzylguanidine (MIBG) myocardial scintigraphy or the odor stick identification test for Japanese (OSIT-J) is effective in differentiating Parkinson's disease (PD) from multiple system atrophy (MSA). We compared the MIBG accumulation and olfactory score between 42 PD and 42 MSA (19 MSA-P and 23 MSA-C) patients in the early stages. [ 123l] MIBG myocardial scintigraphy showed higher sensitivity and the olfactory test higher specificity in differentiating PD from MSA. There were significant differences between PD and MSA-C (p = 0.0019) instead of MSA-P (p > 0.05) in the MIBG accumulation, while there were significant differences between PD and MSA-P (p = 0.0003) or MSA-C (p = 0.0003) in the OSIT-J score. Our data suggest that the olfactory test can be useful as a clinical tool with its higher specificity in differentiating PD from MSA in the early stages and, moreover, support the discrimination of PD from MSA-P.

Original languageEnglish
Pages (from-to)698-700
Number of pages3
JournalParkinsonism and Related Disorders
Volume17
Issue number9
DOIs
Publication statusPublished - 2011 Nov

Keywords

  • Multiple system atrophy (MSA)
  • Olfactory test
  • Parkinson's disease (PD)
  • [123l] myocardial meta-iodobenzylguanidine (MIBG) myocardial scintigraphy

ASJC Scopus subject areas

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

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