Differential responses of mandibular condyle and femur to estrogen deficiency in young rats

T. Yamashiro, T. Takano-Yamamoto

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

This response of condyle and femur was evaluated by histomorphometry. Five female Sprague-Dawley rats, 6 weeks of age, were subjected to bilateral ovariectomy, and five others were sham-operated. They were then killed 32 days later. Ovariectomy significantly increased the total thickness of the condylar cartilage and distal femoral growth-plate cartilage in the young, growing rats. Ovariectomy caused a 2-fold increase in thickness of the proliferative layer and a 4-fold increase in thickness of the hypertrophic layer in the condylar cartilage, and distal a 1.3-fold increase in thickness of the proliferative layer in the epiphyseal growth cartilage of the femur. Ovariectomy had no effect on the percentage of trabecular bone volume, the percentage of the bone surface covered by osteoblasts (Ob.S/BS) and osteoclasts (Oc.S/BS), and number of osteoclasts per bone surface (N.Oc/BS) in the mandibular condyle. On the contrary, ovariectomy caused a 68.5% decrease in bone volume, a 4-fold increase in Ob.S/BS, and 2-fold increases in Oc.S/BS and N.Oc/BS in the secondary spongiosa of the rat distal femur. Thus there was a prominent difference in the response to oestrogen deficiency between the mandibular condyle and femur in young growing rats.

Original languageEnglish
Pages (from-to)191-195
Number of pages5
JournalArchives of Oral Biology
Volume43
Issue number3
DOIs
Publication statusPublished - 1998 Mar
Externally publishedYes

Keywords

  • Bone histomorphometry
  • Femur
  • Mandibular condyle
  • Ovariectomy
  • Rat

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Dentistry(all)
  • Cell Biology

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