TY - JOUR
T1 - Differential responding of autonomic function to histamine H1 antagonism in irritable bowel syndrome
AU - Hattori, T.
AU - Watanabe, S.
AU - Kano, M.
AU - Kanazawa, M.
AU - Fukudo, S.
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2010/12
Y1 - 2010/12
N2 - Background: The role of histamine in the pathophysiology of irritable bowel syndrome (IBS) is largely unknown. Dysfunction of the autonomic nervous system (ANS) in IBS patients is also not fully confirmed. We hypothesized that blockade of histamine H1 receptors affects ANS responses differently between IBS subjects and controls. Methods: Subjects were 12 IBS subjects and 12 age- and sex-matched controls. Either 100-μg-kg-1 chlorphenamine or the same amount of saline was administered on different days. The rectum was stimulated with electrical currents of 0-mA (sham) or 30-mA. Autonomic nervous system function was measured using mean arterial pressure (MAP), heart rate (HR), high frequency (HF) component of HR variability, low frequency/high frequency ratio (LF/HF ratio) and plasma catecholamines and histamine. Subjective perceived stress during the examination was evaluated on an ordinate scale. Key Results: Mean arterial pressure showed significant effects of diagnosis (P-<-0.05) and drug-×-diagnosis interaction (P-<-0.05). The MAP significantly increased after chlorphenamine administration in IBS subjects, but not in controls. Heart rate revealed a significant drug effect (P-<-0.001), which decreased after chlorphenamine administration in controls, but not in IBS subjects. Perceived stress significantly increased by rectal stimulation (P-<-0.001) and a significant stimulus-×-diagnosis interaction (P-<-0.05) was revealed, indicating greater reduction in IBS subjects by chlorphenamine.Conclusion & Inferences- Sympathetic vasomotor tone in IBS subjects differentially responded on administration of a histamine H1 antagonist to that of controls. These findings suggest an increased histaminergic activity in IBS subjects.
AB - Background: The role of histamine in the pathophysiology of irritable bowel syndrome (IBS) is largely unknown. Dysfunction of the autonomic nervous system (ANS) in IBS patients is also not fully confirmed. We hypothesized that blockade of histamine H1 receptors affects ANS responses differently between IBS subjects and controls. Methods: Subjects were 12 IBS subjects and 12 age- and sex-matched controls. Either 100-μg-kg-1 chlorphenamine or the same amount of saline was administered on different days. The rectum was stimulated with electrical currents of 0-mA (sham) or 30-mA. Autonomic nervous system function was measured using mean arterial pressure (MAP), heart rate (HR), high frequency (HF) component of HR variability, low frequency/high frequency ratio (LF/HF ratio) and plasma catecholamines and histamine. Subjective perceived stress during the examination was evaluated on an ordinate scale. Key Results: Mean arterial pressure showed significant effects of diagnosis (P-<-0.05) and drug-×-diagnosis interaction (P-<-0.05). The MAP significantly increased after chlorphenamine administration in IBS subjects, but not in controls. Heart rate revealed a significant drug effect (P-<-0.001), which decreased after chlorphenamine administration in controls, but not in IBS subjects. Perceived stress significantly increased by rectal stimulation (P-<-0.001) and a significant stimulus-×-diagnosis interaction (P-<-0.05) was revealed, indicating greater reduction in IBS subjects by chlorphenamine.Conclusion & Inferences- Sympathetic vasomotor tone in IBS subjects differentially responded on administration of a histamine H1 antagonist to that of controls. These findings suggest an increased histaminergic activity in IBS subjects.
KW - Autonomic nervous system
KW - Chlorph-enamine
KW - Histamine Hantagonist
KW - Irritable bowel syndrome
KW - Mean arterial pressure
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U2 - 10.1111/j.1365-2982.2010.01568.x
DO - 10.1111/j.1365-2982.2010.01568.x
M3 - Article
C2 - 20667004
AN - SCOPUS:78349268748
VL - 22
SP - 1284-e335
JO - Neurogastroenterology and Motility
JF - Neurogastroenterology and Motility
SN - 1350-1925
IS - 12
ER -