Differential impacts of duration of untreated psychosis (DUP) on cognitive function in first-episode schizophrenia according to mode of onset

S. Ito, T. Nemoto, N. Tsujino, N. Ohmuro, K. Matsumoto, H. Matsuoka, K. Tanaka, S. Nishiyama, M. Suzuki, H. Kinoshita, H. Ozawa, H. Fujita, S. Shimodera, T. Kishimoto, K. Matsumoto, T. Hasegawa, M. Mizuno

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


Background: The mode of onset and the course of schizophrenia illness exhibit substantial individual variations. Previous studies have pointed out that the mode of onset affects the duration of untreated psychosis (DUP) and clinical outcomes, such as cognitive and social functioning. This study attempted to clarify the association between the DUP and clinical features, taking the different modes of onset into consideration, in a prospective longitudinal study examining patients with first-episode schizophrenia. Methods: This study was conducted in six areas of Japan. Patients with first-episode schizophrenia were followed for over 18 months. Cognitive function, psychopathology, and social functioning were assessed at baseline and at 6, 12, and 18-month follow-up points. Results: We identified 168 patients and sufficient information was available to determine the DUP and the mode of onset for 156 patients (92.9%): 79 had an acute onset, and 77 had an insidious onset. The DUP was significantly associated with quality of life (QOL), social functioning, and cognitive function at most of the follow-up points in the insidious-onset group. The DUP and negative symptoms at baseline were significant predictors of cognitive function at the 18-month follow-up in the insidious-onset group. Conclusions: The present results further support the hypothesis that the DUP affects QOL, social functioning, and cognitive function over the course of illness, especially in patients with an insidious onset. Effective strategies for detecting and caring for individuals with insidious onset early during the course of schizophrenia will be essential for achieving a full patient recovery.

Original languageEnglish
Pages (from-to)995-1001
Number of pages7
JournalEuropean Psychiatry
Issue number8
Publication statusPublished - 2015


  • Cognitive function
  • Duration of untreated psychosis (DUP)
  • First-episode
  • Mode of onset
  • Prospective follow-up
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health


Dive into the research topics of 'Differential impacts of duration of untreated psychosis (DUP) on cognitive function in first-episode schizophrenia according to mode of onset'. Together they form a unique fingerprint.

Cite this