Differential expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in ulcerative colitis and Crohn's disease

Seiji Arihiro, Haruo Ohtani, Manabu Suzuki, Masahiro Murata, Chieko Ejima, Motoji Oki, Yoshitaka Kinouchi, Kouhei Fukushima, Iwao Sasaki, Shiro Nakamura, Takayuki Matsumoto, Akira Torii, Gotaro Toda, Hiroshi Nagura

Research output: Contribution to journalArticlepeer-review

109 Citations (Scopus)

Abstract

Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) is selectively expressed in the endothelial cells of intestinal mucosa and gut-associated lymphoid tissue (GALT). Engagement of MAdCAM-1 to its ligand, integrin α4β7, on lymphocytes is associated with the homing of gut-associated lymphocytes to normal gastrointestinal tract and inflammation sites. The present study was designed to elucidate differences between Crohn's disease (CrD) and ulcerative colitis (UC) from the expression patterns of MAdCAM-1. Samples were taken from 40 patients with CrD and 24 patients with UC at surgical resection. Using frozen sections, immunohistochemistry was performed for MAdCAM-1, E-selectin and CD34. MAdCAM-1+ venules were abundant in inflamed mucosa in both UC and CrD. In contrast, clear differences were noted between UC and CrD in the inflammatory area in the ulcer base, that is, MAdCAM-1+ venules were more abundant in CrD than in UC (P < 0.001), while E-selectin was expressed equally in these venules in both diseases. Furthermore, CrD was characterized by the occurrence of MAdCAM-1+ venules in deeper layers of the intestinal tissue, mainly in lymphoid aggregates. Our data indicated more extensive expression of MAdCAM-1 in CrD, which could contribute not only to mucosal inflammation, but also to transmural inflammation in CrD.

Original languageEnglish
Pages (from-to)367-374
Number of pages8
JournalPathology international
Volume52
Issue number5-6
DOIs
Publication statusPublished - 2002

Keywords

  • Crohn's disease
  • Gut-associated lymphocytes
  • Lymphocyte homing
  • Mucosal addressin cell adhesion molecule-1 (MAdCAM-1)
  • Transmural inflammation
  • Ulcerative colitis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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