Differential CD26-mediated activation of the CD3 and CD2 pathways after CD6-depleted allogeneic bone marrow transplantation

Junichi Kameoka, Toshiya Sato, Yoshihiro Torimoto, Kanji Sugita, Robert J. Soiffer, Stuart F. Schlossman, Jerome Ritz, Chikao Morimoto

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Patients who have undergone allogeneic bone marrow transplantation (allo- BMT) are susceptible to a variety of opportunistic infectious complications in the months to years after engraftment. Impaired in vitro T-cell functions have been documented in these patients, and these T-cell dysfunctions contribute to the prolonged immune deficiency after allo-BMT. In the present study, we examined the expression of CD26 as well as the reconstitution of CD26-mediated T-cell costimulation via the CD3 and CD2 pathways at various times in patients aged greater than 18 years after CD6-positive, T-cell depleted allo-BMT. We found that the percentage of CD26- and CD3-positive cells, as well as the levels of expression of both antigens, was lower than in normal controls during the first 4 months after CD6-depleted allo-BMT. Subsequently, the number of lymphocytes expressing CD3 and CD26 and the quantitative surface expression of CD3 and CD26 were not significantly different in patients and normal controls. Functional studies showed that CD26-mediated T-cell proliferation via the CD3 pathway was considerably improved and almost reached normal levels by 1 year, whereas recovery of CD26-mediated T-cell proliferation via the CD2 pathway was delayed for at least 2 years after CD6-depleted allo-BMT. As CD26 involvement in the regulation of human thymocyte activation is restricted preferentially to the CD3 pathway-unlike its involvement with both CD3 end CD2 pathways of peripheral T cells-our results suggest that the different effects of CD26- mediated costimulation via the CD3 and CD2 pathways after CD6-depleted allo- BMT may be a reflection of peripheral T-cell immaturity in those individuals, similar to that seen in mature medullary thymocytes or cord T lymphocytes.

Original languageEnglish
Pages (from-to)1132-1137
Number of pages6
JournalBlood
Volume85
Issue number4
DOIs
Publication statusPublished - 1995 Feb 15

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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