Differential alteration of hippocampal synaptic strength induced by pituitary adenylate cyclase activating polypeptide-38 (PACAP-38)

Tetsuro Kondo, Takashi Tominaga, Michinori Ichikawa, Toshio Iijima

    Research output: Contribution to journalArticle

    34 Citations (Scopus)

    Abstract

    We investigated the effect of pituitary adenylate cyclase activating polypeptide-38 (PACAP-38) on synaptic transmission in rat hippocampal slices using extracellular recordings. Brief bath application of PACAP-38 induced a long-lasting depression of transmission at the Schaffer collateral-CA1 synapse while at the same time causing enhancement of the perforant path-granule cell synapse in the dentate gyrus. Depression at the CA1 synapse was not occluded by low frequency-induced long-term depression (LTD), nor was enhancement at the granule cell synapse blocked by previous high frequency-induced long-term potentiation (LTP). Both actions of PACAP-38 could be elicited in the presence of an N-methyl-D-aspartate (NMDA) receptor antagonist, or in the presence of inhibitors of cyclic AMP- or Ca2+-dependent protein kinases, suggesting a novel mechanism of synaptic modulation.

    Original languageEnglish
    Pages (from-to)189-192
    Number of pages4
    JournalNeuroscience Letters
    Volume221
    Issue number2-3
    DOIs
    Publication statusPublished - 1997 Feb 5

    Keywords

    • CA1
    • dentate gyrus
    • hippocampal slice
    • long-term depression
    • long-term potentiation
    • pituitary adenylate cyclase activating polypeptide-38
    • protein kinase inhibitors

    ASJC Scopus subject areas

    • Neuroscience(all)

    Fingerprint Dive into the research topics of 'Differential alteration of hippocampal synaptic strength induced by pituitary adenylate cyclase activating polypeptide-38 (PACAP-38)'. Together they form a unique fingerprint.

  • Cite this