Differential actin-regulatory activities of tropomodulin1 and tropomodulin3 with diverse tropomyosin and actin isoforms

Sawako Yamashiro, David S. Gokhin, Zhenhua Sui, Sarah E. Bergeron, Peter A. Rubenstein, Velia M. Fowler

    Research output: Contribution to journalArticlepeer-review

    24 Citations (Scopus)

    Abstract

    Background: Tropomodulins (Tmods) cap pointed ends of actin filaments in a tropomyosin (TM)-dependent manner.Results: Tmod1 and Tmod3 similarly cap actin filaments with diverseTMand actin isoforms, but only Tmod3 sequestersβ- andγcyto-actin monomers.Conclusion: Isoform-specific actin monomer sequestration by Tmod3 may provide a mechanism for actin remodeling inTM-deficient regions of cells.Significance: Defining the actin-regulatory activities of Tmods illuminates cytoskeletal dynamics.

    Original languageEnglish
    Pages (from-to)11616-11629
    Number of pages14
    JournalJournal of Biological Chemistry
    Volume289
    Issue number17
    DOIs
    Publication statusPublished - 2014 Apr 25

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Biology
    • Cell Biology

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