Different sensitivities to agonist of muscarinic acetylcholine receptor subtypes

Hideaki Bujo, Junichi Nakai, Tai Kubo, Kazuhiko Fukuda, Isamu Akiba, Akito Maeda, Masayoshi Mishina, Shosaku Numa

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

Muscarinic acetylcholine receptor (mAChR) III expressed in Xenopus oocytes, like mAChR I, mediates activation of a Ca2+-dependent Cl- current, whereas mAChR IV, like mAChR II, principally induces activation of Na+ and K+ currents in a Ca2+-independent manner. mAChR III has a sensitivity to agonist of about one order of magnitude higher than that of mAChR I in mediating the Ca2+-dependent current response in Xenopus oocytes and in stimulating phosphoinositide hydrolysis in NG108-15 neuroblastoma-glioma hybrid cells. The agonist-binding affinity of mAChR III is also about one order of magnitude higher than that of mAChR I.

Original languageEnglish
Pages (from-to)95-100
Number of pages6
JournalFEBS Letters
Volume240
Issue number1-2
DOIs
Publication statusPublished - 1988 Nov 21
Externally publishedYes

Keywords

  • Agonist-binding affinity
  • Ca-dependent Cl current
  • K current
  • Muscarinic acetylcholine receptor subtype
  • Na current
  • Phosphoinositide hydrolysis
  • Sensitivity to agonist

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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