TY - JOUR
T1 - Different origins of lysophospholipid mediators between coronary and peripheral arteries in acute coronary syndrome
AU - Kurano, Makoto
AU - Kano, Kuniyuki
AU - Dohi, Tomotaka
AU - Matsumoto, Hirotaka
AU - Igarashi, Koji
AU - Nishikawa, Masako
AU - Ohkawa, Ryunosuke
AU - Ikeda, Hitoshi
AU - Miyauchi, Katsumi
AU - Daida, Hiroyuki
AU - Aoki, Junken
AU - Yatomi, Yutaka
N1 - Funding Information:
This work was supported by CREST from JST/AMED, a Grant-in-Aid for Scientific Research on Innovative Areas from the Japan Society for the Promotion of Science 15H05906 (Y.Y.), Japan Society for the Promotion of Science Grant 16H06236 (M.K.), and Banyu Life Science Foundation International (M.K.).
PY - 2017
Y1 - 2017
N2 - Lysophosphatidic acids (LysoPAs) and lysophosphatidylserine (LysoPS) are emerging lipid mediators proposed to be involved in the pathogenesis of acute coronary syndrome (ACS). In this study, we attempted to elucidate how LysoPA and LysoPS become elevated in ACS using human blood samples collected simultaneously from culprit coronary arteries and peripheral arteries in ACS subjects. We found that: 1) the plasma LysoPA, LysoPS, and lysophosphatidylglycerol levels were not different, while the lysophosphatidylcholine (LysoPC), lysophosphatidylinositol, and lysophosphatidylethanolamine (LysoPE) levels were significantly lower in the culprit coronary arteries; 2) the serum autotaxin (ATX) level was lower and the serum phosphatidylserine- specific phospholipase A1 (PS-PLA1) level was higher in the culprit coronary arteries; 3) the LysoPE and ATX levels were significant explanatory factors for the mainly elevated species of LysoPA, except for 22:6 LysoPA, in the peripheral arteries, while the LysoPC and LysoPE levels, but not the ATX level, were explanatory factors in the culprit coronary arteries; and 4) 18:0 and 18:1 LysoPS were significantly correlated with PS-PLA1 only in the culprit coronary arteries. In conclusion, the origins of LysoPA and LysoPS might differ between culprit coronary arteries and peripheral arteries, and substrates for ATX, such as LysoPC and LysoPE, might be important for the generation of LysoPA in ACS.-Kurano, M., K. Kano, T. Dohi, H. Matsumoto, K. Igarashi, M. Nishikawa, R. Ohkawa, H. Ikeda, K. Miyauchi, H. Daida, J. Aoki, and Y. Yatomi. Different origins of lysophospholipid mediators between coronary and peripheral arteries in acute coronary syndrome. J. Lipid Res. 2017. 58: 433-442.
AB - Lysophosphatidic acids (LysoPAs) and lysophosphatidylserine (LysoPS) are emerging lipid mediators proposed to be involved in the pathogenesis of acute coronary syndrome (ACS). In this study, we attempted to elucidate how LysoPA and LysoPS become elevated in ACS using human blood samples collected simultaneously from culprit coronary arteries and peripheral arteries in ACS subjects. We found that: 1) the plasma LysoPA, LysoPS, and lysophosphatidylglycerol levels were not different, while the lysophosphatidylcholine (LysoPC), lysophosphatidylinositol, and lysophosphatidylethanolamine (LysoPE) levels were significantly lower in the culprit coronary arteries; 2) the serum autotaxin (ATX) level was lower and the serum phosphatidylserine- specific phospholipase A1 (PS-PLA1) level was higher in the culprit coronary arteries; 3) the LysoPE and ATX levels were significant explanatory factors for the mainly elevated species of LysoPA, except for 22:6 LysoPA, in the peripheral arteries, while the LysoPC and LysoPE levels, but not the ATX level, were explanatory factors in the culprit coronary arteries; and 4) 18:0 and 18:1 LysoPS were significantly correlated with PS-PLA1 only in the culprit coronary arteries. In conclusion, the origins of LysoPA and LysoPS might differ between culprit coronary arteries and peripheral arteries, and substrates for ATX, such as LysoPC and LysoPE, might be important for the generation of LysoPA in ACS.-Kurano, M., K. Kano, T. Dohi, H. Matsumoto, K. Igarashi, M. Nishikawa, R. Ohkawa, H. Ikeda, K. Miyauchi, H. Daida, J. Aoki, and Y. Yatomi. Different origins of lysophospholipid mediators between coronary and peripheral arteries in acute coronary syndrome. J. Lipid Res. 2017. 58: 433-442.
KW - Acute coronary disease
KW - Lysophosphatidic acids
KW - Lysophosphatidylcholine
KW - Lysophosphatidylethanolamine
KW - Lysophosphatidylserine
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U2 - 10.1194/jlr.P071803
DO - 10.1194/jlr.P071803
M3 - Article
C2 - 28007846
AN - SCOPUS:85011317430
VL - 58
SP - 433
EP - 442
JO - Journal of Lipid Research
JF - Journal of Lipid Research
SN - 0022-2275
IS - 2
ER -