Different features of angiogenesis between ovarian and breast carcinoma

Kentaro Nakayama, Atsuko Kanzaki, Yuji Takebayashi, Masakazu Toi, Hiroko Bando, Takafumi Nabei, Kohji Miyazaki, Manabu Fukumoto

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Angiogenesis assessed by immunohistochemical staining for endothelial cells has been widely accepted as an independent prognostic factor in human breast carcinoma. However, the clinicopathologic significance of angiogenesis is still being argued in ovarian carcinoma. Therefore, we retrospectively analyzed the clinicopathologic significance of angiogenesis in ovarian carcinoma compared with that in breast carcinoma. After vessels were stained with CD34-monoclonal antibody, the areas with the highest number of intratumoral microvessels were assessed in a 200× field in 42 ovarian carcinoma and 41 breast carcinoma. Intratumoral microvessel density (IMD) in ovarian carcinoma was significantly lower than that in breast carcinoma. Further, the difference of IMD from tumor to tumor in ovarian carcinoma was smaller than that in breast carcinoma. IMD was correlated with tumor grade, but not with other clinicopathologic variables in ovarian carcinoma. Although the patients with high-IMD tumor revealed a poorer prognosis than those with low-IMD tumor in breast carcinoma, IMD had no influential effects on the survival of the patients with ovarian carcinoma. Our comparative analysis of IMD in ovarian carcinoma with that in breast carcinoma indicates that angiogenesis may play an important role in the transient of ovarian neoplasms, but not in the progression of ovarian carcinomas, and that the biological roles of angiogenesis might be different, depending on histologic subtype.

Original languageEnglish
Pages (from-to)161-167
Number of pages7
JournalCancer Letters
Volume170
Issue number2
DOIs
Publication statusPublished - 2001 Sep 20

Keywords

  • Angiogenesis
  • Breast carcinoma
  • Intratumoral microvessel density
  • Ovarian carcinoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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