Different expression patterns of TRP genes in murine B and T lymphocytes

Hitoshi Inada, Tohko Iida, Makoto Tominaga

Research output: Contribution to journalArticlepeer-review

62 Citations (Scopus)

Abstract

A prolonged increase in the intracellular calcium concentration ([Ca2+]i) is essential for lymphocyte activation that includes cell proliferation and differentiation. This increase in [Ca2+]i results from Ca2+ release from the intracellular store and the subsequent Ca2+ influx from the extracellular environment via calcium channels located on the plasma membrane. Although transient receptor potential (TRP) channels have been reported to play important roles in the [Ca2+]i increase in lymphocytes, the function of these channels in lymphocyte activation remains unknown. Here, we report the comprehensive expression profile of TRP channel gene families including TRPC, TRPV, and TRPM in the murine immune system. RT-PCR analysis revealed different expression patterns of the TRP channel genes in B and T lymphocytes isolated from the spleen. Therefore, our results provide an appropriate reference of TRP gene expression in murine lymphocytes.

Original languageEnglish
Pages (from-to)762-767
Number of pages6
JournalBiochemical and biophysical research communications
Volume350
Issue number3
DOIs
Publication statusPublished - 2006 Nov 24
Externally publishedYes

Keywords

  • B cells
  • BCL1
  • EL4
  • Murine lymphocytes
  • T cells
  • TRP channels

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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