Different etiologies and prognoses of optic neuritis in demyelinating diseases

Tetsuya Akaishi, Ichiro Nakashima, Takayuki Takeshita, Kimihiko Kaneko, Shunji Mugikura, Douglas Kazutoshi Sato, Toshiyuki Takahashi, Toru Nakazawa, Masashi Aoki, Kazuo Fujihara

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

We compared the clinical features of optic neuritis (ON) that are frequently observed in various central nervous system demyelinating diseases, including multiple sclerosis (MS), anti-aquaporin 4 (AQP4) antibody- and anti-myelin oligodendrocyte glycoprotein (MOG) autoantibody-related diseases. Almost all the AQP4-ON patients were female, whereas half of the MOG-ON patients were male. The ON-onset age was younger in MS-ON and was older in AQP4-ON. The ON-lesion detected using optic MRI in the acute phase was longer in MOG-ON and showed severe swelling and twisting. The worst visual acuity was similar between the diseases; however, the final visual acuity was significantly worse in AQP4-ON.

Original languageEnglish
Pages (from-to)152-157
Number of pages6
JournalJournal of Neuroimmunology
Volume299
DOIs
Publication statusPublished - 2016 Oct 15

Keywords

  • Anti-MOG autoantibody
  • Multiple sclerosis
  • Neuromyelitis optica spectrum disorder
  • Optic MRI
  • Optic neuritis
  • Visual prognosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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