TY - JOUR
T1 - Different etiologies and prognoses of optic neuritis in demyelinating diseases
AU - Akaishi, Tetsuya
AU - Nakashima, Ichiro
AU - Takeshita, Takayuki
AU - Kaneko, Kimihiko
AU - Mugikura, Shunji
AU - Sato, Douglas Kazutoshi
AU - Takahashi, Toshiyuki
AU - Nakazawa, Toru
AU - Aoki, Masashi
AU - Fujihara, Kazuo
N1 - Funding Information:
Dr. Akaishi reports no disclosures. Dr. Nakashima received funding for a trip and speech for Biogen Idec Japan (2012–2014), Tanabe Mitsubishi (2012–2015), Novartis Pharma (2012–2014), served as an editorial board member of Multiple Sclerosis International (2010–present), received grant support from LSI Medience Corporation (2012–2015). Dr. Takeshita reports no disclosures. Dr. Kaneko reports no disclosures. Dr. Mugikura reports no disclosures. Dr. Sato reports no disclosures. Dr. Takahashi reports no disclosures. Dr. Nakazawa reports no disclosures. Dr. Aoki reports no disclosures. Dr. Fujihara reports no disclosures.
Publisher Copyright:
© 2016 Elsevier B.V.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2016/10/15
Y1 - 2016/10/15
N2 - We compared the clinical features of optic neuritis (ON) that are frequently observed in various central nervous system demyelinating diseases, including multiple sclerosis (MS), anti-aquaporin 4 (AQP4) antibody- and anti-myelin oligodendrocyte glycoprotein (MOG) autoantibody-related diseases. Almost all the AQP4-ON patients were female, whereas half of the MOG-ON patients were male. The ON-onset age was younger in MS-ON and was older in AQP4-ON. The ON-lesion detected using optic MRI in the acute phase was longer in MOG-ON and showed severe swelling and twisting. The worst visual acuity was similar between the diseases; however, the final visual acuity was significantly worse in AQP4-ON.
AB - We compared the clinical features of optic neuritis (ON) that are frequently observed in various central nervous system demyelinating diseases, including multiple sclerosis (MS), anti-aquaporin 4 (AQP4) antibody- and anti-myelin oligodendrocyte glycoprotein (MOG) autoantibody-related diseases. Almost all the AQP4-ON patients were female, whereas half of the MOG-ON patients were male. The ON-onset age was younger in MS-ON and was older in AQP4-ON. The ON-lesion detected using optic MRI in the acute phase was longer in MOG-ON and showed severe swelling and twisting. The worst visual acuity was similar between the diseases; however, the final visual acuity was significantly worse in AQP4-ON.
KW - Anti-MOG autoantibody
KW - Multiple sclerosis
KW - Neuromyelitis optica spectrum disorder
KW - Optic MRI
KW - Optic neuritis
KW - Visual prognosis
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U2 - 10.1016/j.jneuroim.2016.09.007
DO - 10.1016/j.jneuroim.2016.09.007
M3 - Article
C2 - 27725114
AN - SCOPUS:84988672535
SN - 0165-5728
VL - 299
SP - 152
EP - 157
JO - Advances in Neuroimmunology
JF - Advances in Neuroimmunology
ER -