Differences of inflammatory mechanisms in asthma and COPD

Masakazu Ichinose

Research output: Contribution to journalReview articlepeer-review

25 Citations (Scopus)

Abstract

Bronchial asthma and chronic obstructive pulmonary disease (COPD) are increasing common diseases. The major pathogenesis of both illnesses is chronic inflammation. However, the inflammatory pattern is distinct in each disease. In asthmatic airways, activated mast cells/eosinophils and T helper 2 lymphocytes (Th2) are predominant. In contrast, macrophages and neutrophils are important in COPD airways/lung. Although nitric oxide (NO) hyperproduction due to inducible NO synthase (iNOS) is observed in asthma and COPD, nitrotyrosine formation via the reaction between NO and O2- in addition to the myeloperoxidase-mediated pathway. These distinct inflammatory patterns in both diseases seem to cause pathological differences in asthma and COPD.

Original languageEnglish
Pages (from-to)307-313
Number of pages7
JournalAllergology International
Volume58
Issue number3
DOIs
Publication statusPublished - 2009

Keywords

  • Bronchomotor tone
  • Inflammatory cells
  • Nitric oxide
  • Oxidative stress
  • Tachykinins

ASJC Scopus subject areas

  • Immunology and Allergy

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