TY - JOUR
T1 - Differences in task-phase-dependent time-frequency patterns of local field potentials in the dorsal and ventral regions of the monkey lateral prefrontal cortex
AU - Sakamoto, Kazuhiro
AU - Kawaguchi, Norihiko
AU - Mushiake, Hajime
N1 - Funding Information:
This work was supported by JSPS KAKENHI Grant Number JP16H06276 (Platform of Advanced Animal Model Support), MEXT KAKENHI Grant Number 15H05879 (Non-linear Neuro-oscillology) and Japan Agency for Medical Research and Development (AMED) under Grant Number JP18dm0207051 . We thank Midori Takahashi and Yasuko Sato for technical helps. Appendix A
Publisher Copyright:
© 2020 Elsevier B.V. and Japan Neuroscience Society
PY - 2020/7
Y1 - 2020/7
N2 - Although the ventral and dorsal regions of the lateral prefrontal cortex (lPFC) are anatomically distinct, their functional differentiation is still controversial. Local field potentials (LFPs) reflect synaptic input and are widely modulated by information from both the external world and the internal state of the brain. However, functional mapping using LFPs has not been fully tested and is expected to provide new insights into their differences. Thus, the present study analyzed the task-phase-dependent modulations of LFPs recorded from the lPFC of monkeys as they performed a shape manipulation task. Hierarchical cluster analyses of the LFP time-frequency spectra revealed characteristic patterns, especially in the theta and low gamma ranges. In particular, the theta range distinguished the ventral and dorsal parts of the lPFC well. The ventral part exhibited a block of similar LFP patterns whereas the dorsal part showed scattered patterns of small or single sites with different LFP patterns. These results suggest that functional segregation within the lPFC, especially between the ventral and dorsal regions, can be evaluated using task-phase-dependent time-frequency modulations in LFPs.
AB - Although the ventral and dorsal regions of the lateral prefrontal cortex (lPFC) are anatomically distinct, their functional differentiation is still controversial. Local field potentials (LFPs) reflect synaptic input and are widely modulated by information from both the external world and the internal state of the brain. However, functional mapping using LFPs has not been fully tested and is expected to provide new insights into their differences. Thus, the present study analyzed the task-phase-dependent modulations of LFPs recorded from the lPFC of monkeys as they performed a shape manipulation task. Hierarchical cluster analyses of the LFP time-frequency spectra revealed characteristic patterns, especially in the theta and low gamma ranges. In particular, the theta range distinguished the ventral and dorsal parts of the lPFC well. The ventral part exhibited a block of similar LFP patterns whereas the dorsal part showed scattered patterns of small or single sites with different LFP patterns. These results suggest that functional segregation within the lPFC, especially between the ventral and dorsal regions, can be evaluated using task-phase-dependent time-frequency modulations in LFPs.
KW - LFP
KW - Lateral prefrontal cortex
KW - Monkey
KW - Shape manipulation task
KW - Spectral pattern classification
KW - Time-frequency spectrum
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U2 - 10.1016/j.neures.2019.12.016
DO - 10.1016/j.neures.2019.12.016
M3 - Article
C2 - 31923449
AN - SCOPUS:85077922827
VL - 156
SP - 41
EP - 49
JO - Neuroscience Research
JF - Neuroscience Research
SN - 0168-0102
ER -