Differences in Candida albicans adhesion to intact and denatured type I collagen in vitro

S. Makihira, H. Nikawa, M. Tamagami, T. Hamada, L. P. Samaranayake

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

An inhibition assay of Candida albicans adhesion to gelatin-immobilized membranes was compared with that to intact type I collagen-immobilized membranes using an arginine-glycine-aspartic acid (RGD) containing peptide. As compared with a protein-free membrane, gelatin and collagen significantly enhanced the adherence of C albicans. The adhesion of the yeast to gelatin was significantly inhibited by the RGD peptides, but not by arginine-glycine-glutamic acid (RGE) peptides. In contrast, attachment to collagen was not inhibited by RGD peptides. These results suggest that the RGD sequence of gelatin and the integrin-like proteins of yeasts may be involved in adherence.

Original languageEnglish
Pages (from-to)129-131
Number of pages3
JournalOral Microbiology and Immunology
Volume17
Issue number2
DOIs
Publication statusPublished - 2002 May 2

Keywords

  • Adhesion
  • Candida albicans
  • Collagen
  • Gelatin

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Dentistry(all)
  • Microbiology (medical)

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