Difference in Laminin Expression Between High and Low Metastatic Cell Clones Derived from Murine Lewis Lung Carcinoma

Koh Nanimi; Ken Satoh; Toshihiko Sakai; Tatsuya Abe; Toshiaki Kikuchi; Toshiaki Kikuchi; Masakichi Motomiya; Mamoru Isemura; Kayoko Oguri; Minoru Okayama

doi:10.1247/csf.18.183

Difference in Laminin Expression Between High and Low Metastatic Cell Clones Derived from Murine Lewis Lung Carcinoma

Koh Nanimi, Ken Satoh, Toshihiko Sakai, Tatsuya Abe, Toshiaki Kikuchi, Toshiaki Kikuchi, Masakichi Motomiya, Mamoru Isemura, Kayoko Oguri, Minoru Okayama

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

We investigated the expression of laminin in two cell lines with different metastatic potentials established from murine Lewis lung carcinoma. Immunostaining of the cells with anti-laminin antibody and Northern blot analysis of laminin mRNA demonstrated that the high metastatic clone expressed less laminin than the low metastatic one. In contrast, expressions of 67 kDa-laminin receptor were at similar levels between these two lines. These findings show the possibility that endogenous laminin may contribute to the difference in metastatic properties in the murine Lewis lung carcinoma cell lines examined.

Original language	English
Pages (from-to)	183-187
Number of pages	5
Journal	Cell structure and function
Volume	18
Issue number	3
DOIs	https://doi.org/10.1247/csf.18.183
Publication status	Published - 1993 Jan 1

Keywords

Laminin
Laminin Receptor
Lewis Lung Carcinoma
Metastasis

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

Access to Document

10.1247/csf.18.183

Cite this

Difference in Laminin Expression Between High and Low Metastatic Cell Clones Derived from Murine Lewis Lung Carcinoma. / Nanimi, Koh; Satoh, Ken; Sakai, Toshihiko; Abe, Tatsuya; Kikuchi, Toshiaki; Kikuchi, Toshiaki; Motomiya, Masakichi; Isemura, Mamoru; Oguri, Kayoko; Okayama, Minoru.

In: Cell structure and function, Vol. 18, No. 3, 01.01.1993, p. 183-187.

Research output: Contribution to journal › Article › peer-review

@article{0ff8717b3f9a4abbafb9d524f12d5534,

title = "Difference in Laminin Expression Between High and Low Metastatic Cell Clones Derived from Murine Lewis Lung Carcinoma",

abstract = "We investigated the expression of laminin in two cell lines with different metastatic potentials established from murine Lewis lung carcinoma. Immunostaining of the cells with anti-laminin antibody and Northern blot analysis of laminin mRNA demonstrated that the high metastatic clone expressed less laminin than the low metastatic one. In contrast, expressions of 67 kDa-laminin receptor were at similar levels between these two lines. These findings show the possibility that endogenous laminin may contribute to the difference in metastatic properties in the murine Lewis lung carcinoma cell lines examined.",

keywords = "Laminin, Laminin Receptor, Lewis Lung Carcinoma, Metastasis",

author = "Koh Nanimi and Ken Satoh and Toshihiko Sakai and Tatsuya Abe and Toshiaki Kikuchi and Toshiaki Kikuchi and Masakichi Motomiya and Mamoru Isemura and Kayoko Oguri and Minoru Okayama",

year = "1993",

month = jan,

day = "1",

doi = "10.1247/csf.18.183",

language = "English",

volume = "18",

pages = "183--187",

journal = "Cell Structure and Function",

issn = "0386-7196",

publisher = "Japan Society for Cell Biology",

number = "3",

}

TY - JOUR

T1 - Difference in Laminin Expression Between High and Low Metastatic Cell Clones Derived from Murine Lewis Lung Carcinoma

AU - Nanimi, Koh

AU - Satoh, Ken

AU - Sakai, Toshihiko

AU - Abe, Tatsuya

AU - Kikuchi, Toshiaki

AU - Motomiya, Masakichi

AU - Isemura, Mamoru

AU - Oguri, Kayoko

AU - Okayama, Minoru

PY - 1993/1/1

Y1 - 1993/1/1

N2 - We investigated the expression of laminin in two cell lines with different metastatic potentials established from murine Lewis lung carcinoma. Immunostaining of the cells with anti-laminin antibody and Northern blot analysis of laminin mRNA demonstrated that the high metastatic clone expressed less laminin than the low metastatic one. In contrast, expressions of 67 kDa-laminin receptor were at similar levels between these two lines. These findings show the possibility that endogenous laminin may contribute to the difference in metastatic properties in the murine Lewis lung carcinoma cell lines examined.

AB - We investigated the expression of laminin in two cell lines with different metastatic potentials established from murine Lewis lung carcinoma. Immunostaining of the cells with anti-laminin antibody and Northern blot analysis of laminin mRNA demonstrated that the high metastatic clone expressed less laminin than the low metastatic one. In contrast, expressions of 67 kDa-laminin receptor were at similar levels between these two lines. These findings show the possibility that endogenous laminin may contribute to the difference in metastatic properties in the murine Lewis lung carcinoma cell lines examined.

KW - Laminin

KW - Laminin Receptor

KW - Lewis Lung Carcinoma

KW - Metastasis

UR - http://www.scopus.com/inward/record.url?scp=0027378195&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027378195&partnerID=8YFLogxK

U2 - 10.1247/csf.18.183

DO - 10.1247/csf.18.183

M3 - Article

C2 - 8242796

AN - SCOPUS:0027378195

VL - 18

SP - 183

EP - 187

JO - Cell Structure and Function

JF - Cell Structure and Function

SN - 0386-7196

IS - 3

ER -

Difference in Laminin Expression Between High and Low Metastatic Cell Clones Derived from Murine Lewis Lung Carcinoma

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this