Difference in Laminin Expression Between High and Low Metastatic Cell Clones Derived from Murine Lewis Lung Carcinoma

Koh Nanimi, Ken Satoh, Toshihiko Sakai, Tatsuya Abe, Toshiaki Kikuchi, Toshiaki Kikuchi, Masakichi Motomiya, Mamoru Isemura, Kayoko Oguri, Minoru Okayama

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

We investigated the expression of laminin in two cell lines with different metastatic potentials established from murine Lewis lung carcinoma. Immunostaining of the cells with anti-laminin antibody and Northern blot analysis of laminin mRNA demonstrated that the high metastatic clone expressed less laminin than the low metastatic one. In contrast, expressions of 67 kDa-laminin receptor were at similar levels between these two lines. These findings show the possibility that endogenous laminin may contribute to the difference in metastatic properties in the murine Lewis lung carcinoma cell lines examined.

Original languageEnglish
Pages (from-to)183-187
Number of pages5
JournalCell structure and function
Volume18
Issue number3
DOIs
Publication statusPublished - 1993 Jan 1

Keywords

  • Laminin
  • Laminin Receptor
  • Lewis Lung Carcinoma
  • Metastasis

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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