Dietary soy protein isolate and its undigested high molecular fraction upregulate hepatic ATP-binding cassette transporter G5 and ATP-binding cassette transporter G8 mRNA and increase biliary secretion of cholesterol in rats

Ikuo Ikeda; Mariko Kudo; Tadateru Hamada; Koji Nagao; Yoko Oshiro; Masaki Kato; Takashi Sugawara; Takashi Yamahira; Hiroko Ito; Shogo Tamaru; Masao Sato; Katsumi Imaizumi; Satoshi Nagaoka; Teruyoshi Y. Anagita

doi:10.3177/jnsv.55.252

Dietary soy protein isolate and its undigested high molecular fraction upregulate hepatic ATP-binding cassette transporter G5 and ATP-binding cassette transporter G8 mRNA and increase biliary secretion of cholesterol in rats

Ikuo Ikeda, Mariko Kudo, Tadateru Hamada, Koji Nagao, Yoko Oshiro, Masaki Kato, Takashi Sugawara, Takashi Yamahira, Hiroko Ito, Shogo Tamaru, Masao Sato, Katsumi Imaizumi, Satoshi Nagaoka, Teruyoshi Y. Anagita

New Industry Creation Hatchery Center (NICHe)

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Dietary soy protein isolate (SPI) and its undigested high molecular fraction (HMF) exhaustively digested with proteases, compared with casein (CAS), significantly reduced serum and liver cholesterol concentration in rats. Biliary excretion of cholesterol was significantly higher in rats fed SPI and HMF than in those fed CAS. Hepatic expression of ATP-binding cassette transporter G5 (ABCG5) and ATP-binding cassette transporter G8 (ABCG8) mRNA was significantly higher in rats fed SPI and HMF than in those fed CAS. These observations suggest that increased biliary excretion of cholesterol in SPI and HMF groups is caused by the enhanced expression of Abcg5/Abcg8.

Original language	English
Pages (from-to)	252-256
Number of pages	5
Journal	Journal of nutritional science and vitaminology
Volume	55
Issue number	3
DOIs	https://doi.org/10.3177/jnsv.55.252
Publication status	Published - 2009

Keywords

ATP-binding cassette transporter G5
ATP-binding cassette transporter G8
Bile
Cholesterol
Soy protein isolate

ASJC Scopus subject areas

Medicine (miscellaneous)
Nutrition and Dietetics

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Ikeda, I., Kudo, M., Hamada, T., Nagao, K., Oshiro, Y., Kato, M., Sugawara, T., Yamahira, T., Ito, H., Tamaru, S., Sato, M., Imaizumi, K., Nagaoka, S., & Anagita, T. Y. (2009). Dietary soy protein isolate and its undigested high molecular fraction upregulate hepatic ATP-binding cassette transporter G5 and ATP-binding cassette transporter G8 mRNA and increase biliary secretion of cholesterol in rats. Journal of nutritional science and vitaminology, 55(3), 252-256. https://doi.org/10.3177/jnsv.55.252

Dietary soy protein isolate and its undigested high molecular fraction upregulate hepatic ATP-binding cassette transporter G5 and ATP-binding cassette transporter G8 mRNA and increase biliary secretion of cholesterol in rats. / Ikeda, Ikuo; Kudo, Mariko; Hamada, Tadateru; Nagao, Koji; Oshiro, Yoko; Kato, Masaki; Sugawara, Takashi; Yamahira, Takashi; Ito, Hiroko; Tamaru, Shogo; Sato, Masao; Imaizumi, Katsumi; Nagaoka, Satoshi; Anagita, Teruyoshi Y.

In: Journal of nutritional science and vitaminology, Vol. 55, No. 3, 2009, p. 252-256.

Research output: Contribution to journal › Article › peer-review

Ikeda, I, Kudo, M, Hamada, T, Nagao, K, Oshiro, Y, Kato, M, Sugawara, T, Yamahira, T, Ito, H, Tamaru, S, Sato, M, Imaizumi, K, Nagaoka, S & Anagita, TY 2009, 'Dietary soy protein isolate and its undigested high molecular fraction upregulate hepatic ATP-binding cassette transporter G5 and ATP-binding cassette transporter G8 mRNA and increase biliary secretion of cholesterol in rats', Journal of nutritional science and vitaminology, vol. 55, no. 3, pp. 252-256. https://doi.org/10.3177/jnsv.55.252

Ikeda I, Kudo M, Hamada T, Nagao K, Oshiro Y, Kato M et al. Dietary soy protein isolate and its undigested high molecular fraction upregulate hepatic ATP-binding cassette transporter G5 and ATP-binding cassette transporter G8 mRNA and increase biliary secretion of cholesterol in rats. Journal of nutritional science and vitaminology. 2009;55(3):252-256. https://doi.org/10.3177/jnsv.55.252

Ikeda, Ikuo ; Kudo, Mariko ; Hamada, Tadateru ; Nagao, Koji ; Oshiro, Yoko ; Kato, Masaki ; Sugawara, Takashi ; Yamahira, Takashi ; Ito, Hiroko ; Tamaru, Shogo ; Sato, Masao ; Imaizumi, Katsumi ; Nagaoka, Satoshi ; Anagita, Teruyoshi Y. / Dietary soy protein isolate and its undigested high molecular fraction upregulate hepatic ATP-binding cassette transporter G5 and ATP-binding cassette transporter G8 mRNA and increase biliary secretion of cholesterol in rats. In: Journal of nutritional science and vitaminology. 2009 ; Vol. 55, No. 3. pp. 252-256.

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abstract = "Dietary soy protein isolate (SPI) and its undigested high molecular fraction (HMF) exhaustively digested with proteases, compared with casein (CAS), significantly reduced serum and liver cholesterol concentration in rats. Biliary excretion of cholesterol was significantly higher in rats fed SPI and HMF than in those fed CAS. Hepatic expression of ATP-binding cassette transporter G5 (ABCG5) and ATP-binding cassette transporter G8 (ABCG8) mRNA was significantly higher in rats fed SPI and HMF than in those fed CAS. These observations suggest that increased biliary excretion of cholesterol in SPI and HMF groups is caused by the enhanced expression of Abcg5/Abcg8.",

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AU - Ikeda, Ikuo

AU - Kudo, Mariko

AU - Hamada, Tadateru

AU - Nagao, Koji

AU - Oshiro, Yoko

AU - Kato, Masaki

AU - Sugawara, Takashi

AU - Yamahira, Takashi

AU - Ito, Hiroko

AU - Tamaru, Shogo

AU - Sato, Masao

AU - Imaizumi, Katsumi

AU - Nagaoka, Satoshi

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AB - Dietary soy protein isolate (SPI) and its undigested high molecular fraction (HMF) exhaustively digested with proteases, compared with casein (CAS), significantly reduced serum and liver cholesterol concentration in rats. Biliary excretion of cholesterol was significantly higher in rats fed SPI and HMF than in those fed CAS. Hepatic expression of ATP-binding cassette transporter G5 (ABCG5) and ATP-binding cassette transporter G8 (ABCG8) mRNA was significantly higher in rats fed SPI and HMF than in those fed CAS. These observations suggest that increased biliary excretion of cholesterol in SPI and HMF groups is caused by the enhanced expression of Abcg5/Abcg8.

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KW - Bile

KW - Cholesterol

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