Dietary gallate esters of tea catechins reduce deposition of visceral fat, hepatic triacylglycerol, and activities of hepatic enzymes related to fatty acid synthesis in rats

Ikuo Ikeda, Reina Hamamoto, Kazunori Uzu, Katsumi Imaizumi, Koji Nagao, Teruyoshi Yanagita, Yuko Suzuki, Makoto Kobayashi, Takami Kakuda

Research output: Contribution to journalArticlepeer-review

71 Citations (Scopus)

Abstract

Tea catechins, rich in (-)-epigallocatechin gallate and (-)-epicatechin gallate, or heat-treated tea catechins in which about 50% of the (-)-epigallocatechin gallate and (-)-epicatechin gallate in tea catechins was epimerized to (-)-gallocatechin gallate and (-)-catechin gallate, were fed to rats at 1% level for 23 d. Visceral fat deposition and the concentration of hepatic triacylglycerol were significantly lower in the tea catechin and heat-treated tea catechin groups than in the control group. The activities of fatty acid synthase and the malic enzyme in the liver cytosol were significantly lower in the two catechin groups than in the control group. In contrast, the activities of carnitine palmitoyltransferase and acyl-CoA oxidase in the liver homogenate were not significantly different among the three groups. These results suggest that the reduction in activities of enzymes related to hepatic fatty acid synthesis by the feeding of tea catechins or heat-treated tea catechins can cause reductions of hepatic triacylglycerol and possibly of visceral fat deposition.

Original languageEnglish
Pages (from-to)1049-1053
Number of pages5
JournalBioscience, Biotechnology and Biochemistry
Volume69
Issue number5
DOIs
Publication statusPublished - 2005 May

Keywords

  • Fatty acid synthase
  • Malic enzyme
  • Rat
  • Tea catechins
  • Visceral fat

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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