Dietary effects of eicosapentaenoic and docosahexaenoic acid esters on lipid metabolism and immune parameters in sprague-dawley rats

Pham Hung, Jiong Yan Gu, Shihoko Kaku, Shin Ichi Yunoki, Ken Ichi Ohkura, Ikuo Ikeda, Hirofumi Tachibana, Michihiro Sugano, Kazunaga Yazawa, Koji Yamada

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

Sprague-Dawley rats were fed eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) ethyl esters at the 2% level for 3 weeks to clarify their effects on immune functions. In the rats fed EPA or DHA, serum cholesterol, triglyceride, and phospholipid (PL) levels were significantly lower than those in the rats fed safflower oil. In PL fractions of serum, liver, lung, splenocytes, and peritoneal exudate cells (PEC), increases in linoleic and dihomo-γ-linolenic acid contents and a decrease in arachidonic acid (AA) content were observed in the rats fed EPA or DHA. In addition, the EPA content increased in the rats fed EPA and DHA. In the rats fed EPA or DHA, a decrease of LTB4 productivity and an increase of LTB5 productivity were observed in the PEC, in response to the treatment with 5 μM calcium ionophore A23187 for 20 min. The changes in leukotriene production were more marked in EPA-fed rats than in DHA-fed rats. These results suggest that dietary EPA affects lipid metabolism and leukotriene synthesis more strongly than DHA.

Original languageEnglish
Pages (from-to)2588-2593
Number of pages6
JournalBioscience, Biotechnology and Biochemistry
Volume64
Issue number12
DOIs
Publication statusPublished - 2000 Jan 1
Externally publishedYes

Keywords

  • DHA
  • EPA
  • Fatty acid composition
  • LTB
  • LTB

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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