Dietary effect of EPA-rich and DHA-rich fish oils on the immune function of sprague-dawley rats

Pham Hung; Shihoko Kaku; Shin Ichi Yunoki; Ken Ichi Ohkura; Jiong Yan Gu; Ikuo Ikeda; Michihiro Sugano; Kazunaga Yazawa; Koji Yamada

doi:10.1271/bbb.63.135

Dietary effect of EPA-rich and DHA-rich fish oils on the immune function of sprague-dawley rats

Pham Hung, Shihoko Kaku, Shin Ichi Yunoki, Ken Ichi Ohkura, Jiong Yan Gu, Ikuo Ikeda, Michihiro Sugano, Kazunaga Yazawa, Koji Yamada

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

The dietary effect of fish oils (FOs) rich in eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) on the immune function of Sprague-Dawley rats was compared with that of safflower oil. After 3 weeks of feeding at the 10% level of a dietary fat, the IgG and IgM production by splenocytes and IgG production by mesenteric lymph node (MLN) lymphocytes were significantly higher in the FO-fed rats, while no significant difference was found in IgA or IgE productivity by both the spleen and MLN lymphocytes. In the FO-fed rats, peritoneal exudate cells released a lower amount of LTB₄, reflecting their lower arachidonic acid level, and a higher amount of LTB₅, reflecting their higher EPA level in phospholipids. On these EPA-rich FO exerted a stronger effect than DHA-rich FO immune functions.

Original language	English
Pages (from-to)	135-140
Number of pages	6
Journal	Bioscience, Biotechnology and Biochemistry
Volume	63
Issue number	1
DOIs	https://doi.org/10.1271/bbb.63.135
Publication status	Published - 1999
Externally published	Yes

Keywords

Fatty acid
Fish oil
Histamine
Immunoglobulin
Leukotriene

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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title = "Dietary effect of EPA-rich and DHA-rich fish oils on the immune function of sprague-dawley rats",

abstract = "The dietary effect of fish oils (FOs) rich in eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) on the immune function of Sprague-Dawley rats was compared with that of safflower oil. After 3 weeks of feeding at the 10% level of a dietary fat, the IgG and IgM production by splenocytes and IgG production by mesenteric lymph node (MLN) lymphocytes were significantly higher in the FO-fed rats, while no significant difference was found in IgA or IgE productivity by both the spleen and MLN lymphocytes. In the FO-fed rats, peritoneal exudate cells released a lower amount of LTB4, reflecting their lower arachidonic acid level, and a higher amount of LTB5, reflecting their higher EPA level in phospholipids. On these EPA-rich FO exerted a stronger effect than DHA-rich FO immune functions.",

keywords = "Fatty acid, Fish oil, Histamine, Immunoglobulin, Leukotriene",

author = "Pham Hung and Shihoko Kaku and Yunoki, {Shin Ichi} and Ohkura, {Ken Ichi} and Gu, {Jiong Yan} and Ikuo Ikeda and Michihiro Sugano and Kazunaga Yazawa and Koji Yamada",

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doi = "10.1271/bbb.63.135",

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AU - Hung, Pham

AU - Kaku, Shihoko

AU - Yunoki, Shin Ichi

AU - Ohkura, Ken Ichi

AU - Gu, Jiong Yan

AU - Ikeda, Ikuo

AU - Sugano, Michihiro

AU - Yazawa, Kazunaga

AU - Yamada, Koji

PY - 1999

Y1 - 1999

N2 - The dietary effect of fish oils (FOs) rich in eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) on the immune function of Sprague-Dawley rats was compared with that of safflower oil. After 3 weeks of feeding at the 10% level of a dietary fat, the IgG and IgM production by splenocytes and IgG production by mesenteric lymph node (MLN) lymphocytes were significantly higher in the FO-fed rats, while no significant difference was found in IgA or IgE productivity by both the spleen and MLN lymphocytes. In the FO-fed rats, peritoneal exudate cells released a lower amount of LTB4, reflecting their lower arachidonic acid level, and a higher amount of LTB5, reflecting their higher EPA level in phospholipids. On these EPA-rich FO exerted a stronger effect than DHA-rich FO immune functions.

AB - The dietary effect of fish oils (FOs) rich in eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) on the immune function of Sprague-Dawley rats was compared with that of safflower oil. After 3 weeks of feeding at the 10% level of a dietary fat, the IgG and IgM production by splenocytes and IgG production by mesenteric lymph node (MLN) lymphocytes were significantly higher in the FO-fed rats, while no significant difference was found in IgA or IgE productivity by both the spleen and MLN lymphocytes. In the FO-fed rats, peritoneal exudate cells released a lower amount of LTB4, reflecting their lower arachidonic acid level, and a higher amount of LTB5, reflecting their higher EPA level in phospholipids. On these EPA-rich FO exerted a stronger effect than DHA-rich FO immune functions.

KW - Fatty acid

KW - Fish oil

KW - Histamine

KW - Immunoglobulin

KW - Leukotriene

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Dietary effect of EPA-rich and DHA-rich fish oils on the immune function of sprague-dawley rats

Abstract

Keywords

ASJC Scopus subject areas

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