Dietary administration of tetrodotoxin and its putative biosynthetic intermediates to the captive-reared non-toxic Japanese fire-bellied newt, Cynops pyrrhogaster

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The origin of tetrodotoxin (TTX) in amphibians has long been disputed. In this study, TTX and its putative biosynthetic intermediates or shunt compounds (4,9-anhydro-10-hemiketal-5-deoxyTTX and Cep-242) were dietary administered to the captive-reared, non-toxic Japanese fire-bellied newt, Cynops pyrrhogaster. After 4 weeks, the ingested compounds were detected mainly in the newt body using liquid chromatography-mass spectrometry (LC-MS), while these compounds were not converted into other TTX analogues in newts.

Original languageEnglish
Pages (from-to)78-82
Number of pages5
JournalToxicon
Volume137
DOIs
Publication statusPublished - 2017 Oct

Keywords

  • Cynops pyrrhogaster
  • LC-MS
  • Newt
  • Tetrodotoxin
  • Toxin administration

ASJC Scopus subject areas

  • Toxicology

Fingerprint Dive into the research topics of 'Dietary administration of tetrodotoxin and its putative biosynthetic intermediates to the captive-reared non-toxic Japanese fire-bellied newt, Cynops pyrrhogaster'. Together they form a unique fingerprint.

  • Cite this