Diastereoselective and enantioselective glyoxylate-ene reaction catalyzed by new class of binaphthol-derived titanium complex

Masahiro Terada, Yukihiro Motoyama, Koichi Mikami

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Diastereo- and enantioselective carbonyl-ene reaction of glyoxylate (2) with trisubstituted olefins (3) catalyzed by chiral titanium complexes (1a), derived from 6,6′-dibromo-1,1′-bi-2-naphthol and diisopropoxytitanium dihalides, is found to provide syn-diastereomers exclusively along with a high level of enantioselectivity.

Original languageEnglish
Pages (from-to)6693-6696
Number of pages4
JournalTetrahedron Letters
Volume35
Issue number36
DOIs
Publication statusPublished - 1994 Sep 5
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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