Diastereo- and Enantioselective Access to Stereotriads through a Flexible Coupling of Substituted Aldehydes and Alkenes

Jing Li, Alexander Preinfalk, Nuno Maulide

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

A flexible redox-neutral coupling of aldehydes and alkenes enables rapid access to stereotriads starting from a single stereocenter with perfect levels of enantio- and diastereoselectivity under mild conditions. The versatility of the method is highlighted by the installation of heteroatoms along the tether, which enables a route to structurally diverse building blocks. The formal synthesis of (+)-neopeltolide further demonstrates the synthetic utility of this approach.

Original languageEnglish
Pages (from-to)5887-5890
Number of pages4
JournalAngewandte Chemie - International Edition
Volume58
Issue number18
DOIs
Publication statusPublished - 2019 Apr 23
Externally publishedYes

Keywords

  • Neopeltolide
  • aldehydes
  • alkenes
  • coupling reactions
  • redox-neutral reactions

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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