Abstract
The diarylprolinol-mediated asymmetric direct cross-aldol reaction of α,β-unsaturated aldehyde as an electrophilic aldehyde was developed. The reaction becomes accelerated by an acid when a carbonyl group is introduced at the γ-position of the α,β-unsaturated aldehyde. Synthetically useful γ,δ-unsaturated β-hydroxy aldehydes were obtained with high anti-selectivity and excellent enantioselectivity.
Original language | English |
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Pages (from-to) | 4146-4149 |
Number of pages | 4 |
Journal | Chemistry - An Asian Journal |
Volume | 14 |
Issue number | 23 |
DOIs | |
Publication status | Published - 2019 Dec 2 |
Keywords
- aldehydes
- aldol reaction
- allyl alcohol
- asymmetric synthesis
- organocatalysis
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry