Diarylprolinol-Mediated Asymmetric Direct Cross-Aldol Reaction of α,β-Unsaturated Aldehyde as an Electrophilic Aldehyde

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Abstract

The diarylprolinol-mediated asymmetric direct cross-aldol reaction of α,β-unsaturated aldehyde as an electrophilic aldehyde was developed. The reaction becomes accelerated by an acid when a carbonyl group is introduced at the γ-position of the α,β-unsaturated aldehyde. Synthetically useful γ,δ-unsaturated β-hydroxy aldehydes were obtained with high anti-selectivity and excellent enantioselectivity.

Original languageEnglish
Pages (from-to)4146-4149
Number of pages4
JournalChemistry - An Asian Journal
Volume14
Issue number23
DOIs
Publication statusPublished - 2019 Dec 2

Keywords

  • aldehydes
  • aldol reaction
  • allyl alcohol
  • asymmetric synthesis
  • organocatalysis

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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