Abstract
The diarylprolinol-mediated asymmetric direct cross-aldol reaction of α,β-unsaturated aldehyde as an electrophilic aldehyde was developed. The reaction becomes accelerated by an acid when a carbonyl group is introduced at the γ-position of the α,β-unsaturated aldehyde. Synthetically useful γ,δ-unsaturated β-hydroxy aldehydes were obtained with high anti-selectivity and excellent enantioselectivity.
| Original language | English |
|---|---|
| Pages (from-to) | 4146-4149 |
| Number of pages | 4 |
| Journal | Chemistry - An Asian Journal |
| Volume | 14 |
| Issue number | 23 |
| DOIs | |
| Publication status | Published - 2019 Dec 2 |
Keywords
- aldehydes
- aldol reaction
- allyl alcohol
- asymmetric synthesis
- organocatalysis
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry