Diarylprolinol in an asymmetric aldol reaction of an α-alkyl-α-oxo aldehyde as an electrophile

Yujiro Hayashi; Yusuke Yasui; Masahiro Kojima; Tsuyoshi Kawamura; Hayato Ishikawa

doi:10.1039/c2cc31230a

Diarylprolinol in an asymmetric aldol reaction of an α-alkyl-α-oxo aldehyde as an electrophile

Yujiro Hayashi, Yusuke Yasui, Masahiro Kojima, Tsuyoshi Kawamura, Hayato Ishikawa

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

The direct aldol reaction of an α-alkyl-α-oxo aldehyde was catalyzed by trifluoromethyl-substituted diarylprolinol 1 to afford a γ-oxo-β-hydroxy-α-substituted aldehyde in good yield with excellent anti-selectivity and excellent enantioselectivity.

Original language	English
Pages (from-to)	4570-4572
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	38
DOIs	https://doi.org/10.1039/c2cc31230a
Publication status	Published - 2012 Apr 11
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c2cc31230a

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title = "Diarylprolinol in an asymmetric aldol reaction of an α-alkyl-α-oxo aldehyde as an electrophile",

abstract = "The direct aldol reaction of an α-alkyl-α-oxo aldehyde was catalyzed by trifluoromethyl-substituted diarylprolinol 1 to afford a γ-oxo-β-hydroxy-α-substituted aldehyde in good yield with excellent anti-selectivity and excellent enantioselectivity.",

author = "Yujiro Hayashi and Yusuke Yasui and Masahiro Kojima and Tsuyoshi Kawamura and Hayato Ishikawa",

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T1 - Diarylprolinol in an asymmetric aldol reaction of an α-alkyl-α-oxo aldehyde as an electrophile

AU - Hayashi, Yujiro

AU - Yasui, Yusuke

AU - Kojima, Masahiro

AU - Kawamura, Tsuyoshi

AU - Ishikawa, Hayato

PY - 2012/4/11

Y1 - 2012/4/11

N2 - The direct aldol reaction of an α-alkyl-α-oxo aldehyde was catalyzed by trifluoromethyl-substituted diarylprolinol 1 to afford a γ-oxo-β-hydroxy-α-substituted aldehyde in good yield with excellent anti-selectivity and excellent enantioselectivity.

AB - The direct aldol reaction of an α-alkyl-α-oxo aldehyde was catalyzed by trifluoromethyl-substituted diarylprolinol 1 to afford a γ-oxo-β-hydroxy-α-substituted aldehyde in good yield with excellent anti-selectivity and excellent enantioselectivity.

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DO - 10.1039/c2cc31230a

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JO - Chemical Communications

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ER -

Diarylprolinol in an asymmetric aldol reaction of an α-alkyl-α-oxo aldehyde as an electrophile

Abstract

ASJC Scopus subject areas

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