Diarylprolinol in an asymmetric aldol reaction of an α-alkyl-α-oxo aldehyde as an electrophile

Yujiro Hayashi, Yusuke Yasui, Masahiro Kojima, Tsuyoshi Kawamura, Hayato Ishikawa

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

The direct aldol reaction of an α-alkyl-α-oxo aldehyde was catalyzed by trifluoromethyl-substituted diarylprolinol 1 to afford a γ-oxo-β-hydroxy-α-substituted aldehyde in good yield with excellent anti-selectivity and excellent enantioselectivity.

Original languageEnglish
Pages (from-to)4570-4572
Number of pages3
JournalChemical Communications
Volume48
Issue number38
DOIs
Publication statusPublished - 2012 Apr 11
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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