Diaryl-substituted ortho-carboranes as a new class of hypoxia inducible factor-1α inhibitors

Hiroyuki Nakamura, Lisa Tasaki, Daisuke Kanoh, Shinichi Sato, Hyun Seung Ban

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Diaryl-substituted ortho-carboranes 1 were synthesized from the corresponding alkynes by decaborane coupling under microwave-irradiated conditions with a combination of N,N-dimethylaniline and chlorobenzene. Among the compounds synthesized, 1a and 1d exhibited significant inhibition of hypoxia-induced HIF-1 transcriptional activity. Both compounds similarly suppressed hypoxia-induced HIF-1α accumulation in a concentration- dependent manner without affecting HIF-1α mRNA expression.

Original languageEnglish
Pages (from-to)4941-4944
Number of pages4
JournalDalton Transactions
Issue number13
Publication statusPublished - 2014 Apr 7
Externally publishedYes

ASJC Scopus subject areas

  • Inorganic Chemistry


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