Dialyzer-related thrombocytopenia due to a polysulfone membrane

Eri Kobari, Hiroyuki Terawaki, Yasuhito Takahashi, Yuki Kusano, Kaoru Sakurai, Keiko Matsunaga, Naotaro Fukushima, Sawako Suzuki, Ken Ichi Tanaka, Yoshimitsu Hayashi, Tsuyoshi Watanabe, Masaaki Nakayama

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


A 72-year-old Japanese woman was admitted to our hospital with rapidly progressive glomerulonephritis associated with anti-glomerular basement membrane antibody. Hemodialysis (HD) therapy was initiated on the day of admission using a biocompatible polysulfone (PS) membrane. Her platelet count (PLT; ×104/μL) decreased gradually from 58.7 (day 1) to 5.8 (day 25). Considering the possibility of dialyzer-related thrombocytopenia (DRT), we measured her PLT count before and after the HD session on day 72, which revealed a dramatic decrease of 7.5 to 4.3. This finding suggested that the PS dialyzer caused PLT depletion. After discontinuation of the PS dialyzer, DRT was resolved.

Original languageEnglish
Pages (from-to)965-968
Number of pages4
JournalInternal Medicine
Issue number8
Publication statusPublished - 2016 Apr 15


  • Hemodialysis
  • Polysulfone
  • Thrombocytopenia

ASJC Scopus subject areas

  • Internal Medicine


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