Dialyzable uremic solutes contribute to enhanced oxidation of serum albumin in regular hemodialysis patients

Hiroyuki Terawaki, Keisuke Nakayama, Yukie Matsuyama, Masaaki Nakayama, Toshinobu Sato, Tatsuo Hosoya, Seiichi Era, Sadayoshi Ito

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Background: Oxidative stress (OS) is reportedly enhanced in patients receiving regular hemodialysis (HD). However, the in vivo redox state of HD patients, particularly after HD sessions, remains unclear. This study aimed to clarify the influence of HD on OS using the albumin redox state as a marker. Method: Blood samples of 8 regular HD patients were obtained during the course of study. The redox state of albumin was determined using high-performance liquid chromatography. Results: The mean fraction of reversibly oxidized albumin [f(HNA-1)] declined significantly over the course of the session and reached a minimum 4 h after the session had ended (pre-HD, 36.16 ± 7.50%; 4 h after HD, 25.71 ± 6.41%), then gradually rose to predialytic levels. The proportion of irreversibly oxidized albumin did not change significantly over time. Positive correlations were demonstrated between f(HNA-1) and uremic small solutes in each case. Conclusion: Accumulation of dialyzable uremic solutes may contribute to OS in HD patients.

Original languageEnglish
Pages (from-to)274-279
Number of pages6
JournalBlood Purification
Volume25
Issue number3
DOIs
Publication statusPublished - 2007 Jul

Keywords

  • Albumin redox state
  • Dialyzable solute
  • Hemodialysis
  • Oxidative stress

ASJC Scopus subject areas

  • Hematology
  • Nephrology

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