Diagnostic value of antibody responses to multiple antigens from Mycobacterium tuberculosis in active and latent tuberculosis

Muhammad Andrian Senoputra, Beata Shiratori, Fakhrial Mirwan Hasibuan, Raspati Cundarani Koesoemadinata, Lika Apriani, Yugo Ashino, Kenji Ono, Tetsuya Oda, Makoto Matsumoto, Yasuhiko Suzuki, Bachti Alisjahbana, Toshio Hattori

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

We investigated the antibody responses to 10 prospective Mycobacterium tuberculosis (MTB) antigens and evaluated their ability to discriminate between latent (LTBI) and active pulmonary tuberculosis (TB). Our results indicate that plasma levels of anti-α-crystallin (ACR), antilipoarabinomannan, anti-trehalose 6,6'-dimycolate, and anti-tubercular-glycolipid antigen antibodies were higher in patients with active TB, compared to those in the LTBI and control subjects. No differences in the antibodies were observed between the control and LTBI subjects. Antibodies against the glycolipid antigens could not distinguish between Mycobacterium avium complex (MAC)-negative TB patients and MAC-infected LTBI individuals. The most useful serological marker was antibodies to ACR, with MAC-negative TB patients having higher titers than those observed in MAC-positive LTBI and control subjects. Our data indicate that antibody to ACR is a promising target for the serological diagnosis of patients with active TB patients. When dealing with antiglycolipid antibodies, MAC coinfection should always be considered in serological studies.

Original languageEnglish
Pages (from-to)278-285
Number of pages8
JournalDiagnostic Microbiology and Infectious Disease
Volume83
Issue number3
DOIs
Publication statusPublished - 2015 Nov

Keywords

  • Lipoarabinomannan
  • Mycolic acid
  • Tubercular-glycolipid
  • Tuberculosis
  • α-Crystallin

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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