Diagnosing endometrial carcinoma with cervical involvement by cervical cytology

Yutaka Morimura, Hiroshi Nishiyama, Toshihiro Hashimoto, Yoshimasa Takano, Hidekazu Yamada, Kaoru Yanagida, Akira Sato

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Abstract

    OBJECTIVE: To assess the relationship of a cervical cytologic diagnosis based on number, size and degeneration of malignant clusters and necrotic background to cervical involvement of endometrial carcinoma. STUDY DESIGN: Cervical smears of 53 women with endometrial carcinoma were evaluated for cervical involvement. The cytologic diagnosis was compared with actual involvement, and accuracy was calculated. Retrospectively, cytologic features, including number, size and degeneration of malignant clusters and necrotic background, were analyzed in involved and noninvolved cases. RESULTS: Cervical involvement was confirmed in 15 patients (28.3%). The number and size of malignant clusters in the involved cases were significantly larger than those in the noninvolved cases (P<.001 and <.01, respectively). The proportion of degenerated malignant cells and necrotic background in involved cases were significantly higher than those in noninvolved cases (P<.05). Cytologic diagnosis had a sensitivity and specificity of 62.5% and 86.8%, respectively. CONCLUSION: Cervical smears of involved cases revealed a large number and large size of malignant clusters. These findings support cytologic diagnosis based on number, size and degeneration of malignant cells and necrotic background. Cervical cytology is useful to exclude cervical involvement because of its high specificity and can help detect cervical involvement because of its moderately high sensitivity.

    Original languageEnglish
    Pages (from-to)284-290
    Number of pages7
    JournalActa Cytologica
    Volume46
    Issue number2
    DOIs
    Publication statusPublished - 2002 Jan 1

    Keywords

    • Cervical smears
    • Cervix neoplasms
    • Endometrial neoplasms

    ASJC Scopus subject areas

    • Pathology and Forensic Medicine
    • Histology

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  • Cite this

    Morimura, Y., Nishiyama, H., Hashimoto, T., Takano, Y., Yamada, H., Yanagida, K., & Sato, A. (2002). Diagnosing endometrial carcinoma with cervical involvement by cervical cytology. Acta Cytologica, 46(2), 284-290. https://doi.org/10.1159/000326723