Diabetic nephropathy is markedly enhanced in mice lacking the bradykinin B2 receptor

Masao Kakoki, Nobuyuki Takahashi, J. Charles Jennette, Oliver Smithies

Research output: Contribution to journalArticlepeer-review

103 Citations (Scopus)

Abstract

Type I human diabetics and streptozotocin-induced diabetic mice with higher genetically determined levels of angiotensin-converting enzyme have an increased risk of developing nephropathy. However, previous experiments in mice and computer simulations indicate that modest increases in angiotensin- converting enzyme have minimal effects on blood pressure and angiotensin II levels, although bradykinin decreases significantly, inferring that bradykinin is critical for protecting the kidney in diabetics. Here, we confirm this inference by demonstrating that Akita diabetic mice lacking the bradykinin B2 receptor develop overt albuminuria, excreting the equivalent of >550 mg/day albumin in humans, which contrasts with the microalbuminuria (equivalent to <150 mg/day) seen in their simply diabetic littermates. The overt albuminuria is accompanied by a marked increase in glomerular mesangial sclerosis. The importance of bradykinin demonstrated here bears strongly on how current drugs reduce diabetic nephropathy and suggests that B2 receptor-specific agonists merit consideration in this context.

Original languageEnglish
Pages (from-to)13302-13305
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume101
Issue number36
DOIs
Publication statusPublished - 2004 Sep 7
Externally publishedYes

Keywords

  • Albuminuria
  • Glomerulosclerosis
  • Maturity onset diabetes of the young

ASJC Scopus subject areas

  • General

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