TY - JOUR
T1 - Di- tert-butyl Peroxide (DTBP)-Mediated Oxysilylation of Unsaturated Carboxylic Acids for the Synthesis of Silyl Lactones
AU - Nozawa-Kumada, Kanako
AU - Ojima, Takuto
AU - Inagi, Moeto
AU - Shigeno, Masanori
AU - Kondo, Yoshinori
N1 - Funding Information:
This work was financially supported by the Japan Society for the Promotion of Science (JSPS) KAKENHI Grant Nos. 19H03346 and 19K16309. This work was also supported by Grand for Basic Science Research Projects from Takahashi Industrial and Economic Research Foundation, Yamaguchi Educational and Scholarship Foundation, FUJIFILM Award in Synthetic Organic Chemistry, Japan, and the Platform Project for Supporting Drug Discovery and Life Science Research funded by Japan Agency for Medical Research and Development (AMED).
PY - 2020/12/18
Y1 - 2020/12/18
N2 - Herein, we describe the first oxysilylation of unsaturated carboxylic acids mediated by di-tert-butyl peroxide (DTBP), which enables the rapid and efficient preparation of silyl lactone compounds. This process tolerates functional groups, such as methyl, methoxy, halogen (fluoride and chloride), and cyano moieties. Furthermore, the strategy allows the application of a wide range of primary, secondary, and tertiary hydrosilanes for functionalization.
AB - Herein, we describe the first oxysilylation of unsaturated carboxylic acids mediated by di-tert-butyl peroxide (DTBP), which enables the rapid and efficient preparation of silyl lactone compounds. This process tolerates functional groups, such as methyl, methoxy, halogen (fluoride and chloride), and cyano moieties. Furthermore, the strategy allows the application of a wide range of primary, secondary, and tertiary hydrosilanes for functionalization.
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U2 - 10.1021/acs.orglett.0c03640
DO - 10.1021/acs.orglett.0c03640
M3 - Article
C2 - 33269934
AN - SCOPUS:85097797592
SN - 1523-7060
VL - 22
SP - 9591
EP - 9596
JO - Organic Letters
JF - Organic Letters
IS - 24
ER -