Developmental anatomy of reeler mutant mouse

Yu Katsuyama, Toshio Terashima

    Research output: Contribution to journalReview articlepeer-review

    45 Citations (Scopus)

    Abstract

    The reeler mouse is one of the most famous spontaneously occurring mutants in the research field of neuroscience, and this mutant has been used as a model animal to understand mammalian brain development. The classical observations emphasized that laminar structures of the reeler brain are highly disrupted. Molecular cloning of Reelin, the gene responsible for reeler mutant provided insights into biochemistry of Reelin signal, and some models had been proposed to explain the function of Reelin signal in brain development. However, recent reports of reeler found that non-laminated structures in the central nervous system are also affected by the mutation, making function of Reelin signal more controversial. In this review, we summarized reported morphological and histological abnormalities throughout the central nervous system of the reeler comparing to those of the normal mouse. Based on this overview of the reeler abnormalities, we discuss possible function of Reelin signal in the neuronal migration and other morphological events in mouse development.

    Original languageEnglish
    Pages (from-to)271-286
    Number of pages16
    JournalDevelopment Growth and Differentiation
    Volume51
    Issue number3
    DOIs
    Publication statusPublished - 2009 Apr

    Keywords

    • Brain morphogenesis
    • Neuronal migration
    • Reeler
    • Reelin signal

    ASJC Scopus subject areas

    • Developmental Biology
    • Cell Biology

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