TY - GEN
T1 - Development of UV thermal lens microscope (UV-TLM) for ultrasensitive and direct detection of non-labeled biomolecules on a microchip
AU - Tokeshi, Manabu
AU - Hiki, Shinichiro
AU - Mawatari, Kazuma
AU - Hibara, Akihide
AU - Kitamori, Takehiko
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2005
Y1 - 2005
N2 - This paper describes the development of an ultraviolet thermal lens microscope (UVTLM) that can detect directly non-labeled biomolecules in microchips. The performance of the UV-TLM was evaluated by the limit of detection (LOD) using standard solution of adenine. The LOD for adenine was calculated to be 1.4×10-8 M. This sensitivity was 100 times higher than that obtained by conventional spectrophotometry.
AB - This paper describes the development of an ultraviolet thermal lens microscope (UVTLM) that can detect directly non-labeled biomolecules in microchips. The performance of the UV-TLM was evaluated by the limit of detection (LOD) using standard solution of adenine. The LOD for adenine was calculated to be 1.4×10-8 M. This sensitivity was 100 times higher than that obtained by conventional spectrophotometry.
KW - Non-labeled biomolecules
KW - Quasi-continuous wave
KW - Thermal lens microscope
KW - Ultraviolet pulse laser
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M3 - Conference contribution
AN - SCOPUS:84902517058
SN - 0974361119
SN - 9780974361116
T3 - Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
SP - 452
EP - 454
BT - Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference
PB - Transducer Research Foundation
T2 - 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005
Y2 - 9 October 2005 through 13 October 2005
ER -