Development of UV thermal lens microscope (UV-TLM) for ultrasensitive and direct detection of non-labeled biomolecules on a microchip

Manabu Tokeshi, Shinichiro Hiki, Kazuma Mawatari, Akihide Hibara, Takehiko Kitamori

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper describes the development of an ultraviolet thermal lens microscope (UVTLM) that can detect directly non-labeled biomolecules in microchips. The performance of the UV-TLM was evaluated by the limit of detection (LOD) using standard solution of adenine. The LOD for adenine was calculated to be 1.4×10-8 M. This sensitivity was 100 times higher than that obtained by conventional spectrophotometry.

Original languageEnglish
Title of host publicationMicro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference
Subtitle of host publication9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherTransducer Research Foundation
Pages452-454
Number of pages3
ISBN (Print)0974361119, 9780974361116
Publication statusPublished - 2005
Externally publishedYes
Event9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005 - Boston, MA, United States
Duration: 2005 Oct 92005 Oct 13

Publication series

NameMicro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Volume1

Other

Other9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005
Country/TerritoryUnited States
CityBoston, MA
Period05/10/905/10/13

Keywords

  • Non-labeled biomolecules
  • Quasi-continuous wave
  • Thermal lens microscope
  • Ultraviolet pulse laser

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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