Development of the novel drug releasing system triggered by hybridization with target sequence

F. Nagatsugi; Shizuka Nakayama; Shigeki Sasaki

doi:10.1080/15257770701503597

Development of the novel drug releasing system triggered by hybridization with target sequence

F. Nagatsugi, Shizuka Nakayama, Shigeki Sasaki

Division of Organic- and Biomaterials Research

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

We have already established the strategy of synchronous activation by hybridization, in which the highly reactive cross-linking agent, 2-amino-6-vinylpurine nucleoside analog, can be generated from its stable precursors, the phenylsulfide derivatives, by a hybridization-promoted activation process with selectivity to cytosine. In this study, this in situ activation system was applied to the method for the drug releasing system triggered by hybridization with the target sequence.

Original language	English
Pages (from-to)	799-803
Number of pages	5
Journal	Nucleosides, Nucleotides and Nucleic Acids
Volume	26
Issue number	6-7
DOIs	https://doi.org/10.1080/15257770701503597
Publication status	Published - 2007 Jun

Keywords

2-amino-6-vinylpurine
Cross-link
Drug releasing system
FRET
Oligonucleotides
Synchronous activation

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Genetics

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10.1080/15257770701503597

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keywords = "2-amino-6-vinylpurine, Cross-link, Drug releasing system, FRET, Oligonucleotides, Synchronous activation",

author = "F. Nagatsugi and Shizuka Nakayama and Shigeki Sasaki",

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KW - 2-amino-6-vinylpurine

KW - Cross-link

KW - Drug releasing system

KW - FRET

KW - Oligonucleotides

KW - Synchronous activation

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Development of the novel drug releasing system triggered by hybridization with target sequence

Abstract

Keywords

ASJC Scopus subject areas

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