Development of the highly selective reactions to target gene for the control of the gene expression in cells

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1 Citation (Scopus)

Abstract

The site-specific reaction with high efficiency and specificity to DNA or RNA has become of great interests, as such modification may have possibility to induce point mutation of a genetic code. The cross-linking reagents within complementary duplexes and triplexes are one of the tools for site-specific modification by forming covalently bond. However, the existing alkylating agents still need further improvement for application in either in vitro or in vivo study. Previously, we have designed a new cross-linking motif, 2-amino-6-vinylpurine (1), toward cytosine by expecting a proximity effect within the complex resembling a natural G-C pair. In this paper, we wish to describe the development of the novel cross-linking reagents based on the structure of 1.

Original languageEnglish
Pages (from-to)108-117
Number of pages10
JournalYuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
Volume69
Issue number2
DOIs
Publication statusPublished - 2011 Dec 1

Keywords

  • Antigene
  • Antisense
  • Cross-linking
  • DNA
  • MiRNA
  • Oligonucleotide
  • Sequence and base specific reaction

ASJC Scopus subject areas

  • Organic Chemistry

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