Development of the crosslinking reactions to RNA triggered by oxidation

Shuhei Kusano, Takuya Haruyama, Shogo Ishiyama, Shinya Hagihara, Fumi Nagatsugi

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


A novel crosslink-forming nucleobase, 2-amino-6-(1-ethylthiovinyl)purine (ATVP), which is triggered by the oxidation of sulfide to sulfoxide, has been developed. The oxidation of ATVP within the duplex proceeded with H2O2 and FeCl2. We have successfully developed the crosslinking reactions activated by oxidation.

Original languageEnglish
Pages (from-to)3951-3954
Number of pages4
JournalChemical Communications
Issue number30
Publication statusPublished - 2014 Mar 18

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry


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