Development of the crosslinking reactions to RNA triggered by oxidation

Shuhei Kusano; Takuya Haruyama; Shogo Ishiyama; Shinya Hagihara; Fumi Nagatsugi

doi:10.1039/c3cc49463b

Development of the crosslinking reactions to RNA triggered by oxidation

Shuhei Kusano, Takuya Haruyama, Shogo Ishiyama, Shinya Hagihara, Fumi Nagatsugi

Division of Organic- and Biomaterials Research

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

A novel crosslink-forming nucleobase, 2-amino-6-(1-ethylthiovinyl)purine (ATVP), which is triggered by the oxidation of sulfide to sulfoxide, has been developed. The oxidation of ATVP within the duplex proceeded with H₂O₂ and FeCl₂. We have successfully developed the crosslinking reactions activated by oxidation.

Original language	English
Pages (from-to)	3951-3954
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	30
DOIs	https://doi.org/10.1039/c3cc49463b
Publication status	Published - 2014 Mar 18

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c3cc49463b

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title = "Development of the crosslinking reactions to RNA triggered by oxidation",

abstract = "A novel crosslink-forming nucleobase, 2-amino-6-(1-ethylthiovinyl)purine (ATVP), which is triggered by the oxidation of sulfide to sulfoxide, has been developed. The oxidation of ATVP within the duplex proceeded with H2O2 and FeCl2. We have successfully developed the crosslinking reactions activated by oxidation.",

author = "Shuhei Kusano and Takuya Haruyama and Shogo Ishiyama and Shinya Hagihara and Fumi Nagatsugi",

year = "2014",

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T1 - Development of the crosslinking reactions to RNA triggered by oxidation

AU - Kusano, Shuhei

AU - Haruyama, Takuya

AU - Ishiyama, Shogo

AU - Hagihara, Shinya

AU - Nagatsugi, Fumi

PY - 2014/3/18

Y1 - 2014/3/18

N2 - A novel crosslink-forming nucleobase, 2-amino-6-(1-ethylthiovinyl)purine (ATVP), which is triggered by the oxidation of sulfide to sulfoxide, has been developed. The oxidation of ATVP within the duplex proceeded with H2O2 and FeCl2. We have successfully developed the crosslinking reactions activated by oxidation.

AB - A novel crosslink-forming nucleobase, 2-amino-6-(1-ethylthiovinyl)purine (ATVP), which is triggered by the oxidation of sulfide to sulfoxide, has been developed. The oxidation of ATVP within the duplex proceeded with H2O2 and FeCl2. We have successfully developed the crosslinking reactions activated by oxidation.

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Development of the crosslinking reactions to RNA triggered by oxidation

Abstract

ASJC Scopus subject areas

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