Development of surface-functionalized drug-eluting stent with diamond-like carbon nanocoated by using PECVD method

Keishi Okamoto, Tatsuyuki Nakatani, Shuzou Yamashita, Susumu Takabayashi, Takayuki Takahagi

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

We attempted the surface modification of stents using functionalised functionalized DLC films in order to improve the adhesion and integrity of drug drug-eluting polymers. We doped Si for the improvement of mechanical properties of DLC films, and modified the surface of DLC films using oxygen plasma. The result of the analysis after the plasma treatment showed that oxidation of Si occurred, and that the introduction of O{double bond, short} C-O bonding decreased as the amount of doped Si increased. We deduced that the reduction of Si concentrations from the surface of DLC films was effective for introducing O{double bond, short}C-O bonding. The results obtained from these composition analyses were applied to drug-eluting stents and it was confirmed that the peeling of polymers did not readily occur.

Original languageEnglish
Pages (from-to)5750-5752
Number of pages3
JournalSurface and Coatings Technology
Volume202
Issue number22-23
DOIs
Publication statusPublished - 2008 Aug 30

Keywords

  • Diamond-like carbon
  • Drug-eluting stent
  • Surface treatment
  • XPS

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Surfaces, Coatings and Films
  • Materials Chemistry

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