Development of [ 18F]FRP-170 injection for imaging hypoxia by PET

Yoichi Ishikawa; Yoshihito Funaki; Ren Iwata; Shozo Furumoto; Eiko Nakata; Yukitsuka Kudo; Tomohiro Kaneta; Takashi Hakamatsuka; Yoshihiro Takai; Shogo Yamada

Development of [ ¹⁸F]FRP-170 injection for imaging hypoxia by PET

Yoichi Ishikawa, Yoshihito Funaki, Ren Iwata, Shozo Furumoto, Eiko Nakata, Yukitsuka Kudo, Tomohiro Kaneta, Takashi Hakamatsuka, Yoshihiro Takai, Shogo Yamada

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

A novel [ ¹⁸F]FRP-170 injection for imaging hypoxia by PET was developed for clinical use. The preparation was based on the simple on-column basic-hydrolysis and the whole procedure was automated by detecting He flow change for transferring and evaporating liquids. [ ¹⁸F]FRP-170 was prepared in around 15-20% decay-corrected radiochemical yield within 60 min and stable in saline for more than 6 hr. Radiochemical purity was over 99% and specific activity at EOS was 40-60 GBq/μmol. The radiation-absorbed dose to the whole body was estimated to be 1.0 mSv/185 MBq. The [ ¹⁸F]FRP-170 injection proved to be suitable for clinical use without acute toxicity or mutagenicity.

Original language	English
Pages (from-to)	1-10
Number of pages	10
Journal	Kakuigaku
Volume	42
Issue number	1
Publication status	Published - 2005 Apr 22

Keywords

Automated synthesis
F-18
FRP-170
Hypoxic cell maker
PET radiopharmaceutical

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Cite this

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title = "Development of [ 18F]FRP-170 injection for imaging hypoxia by PET",

abstract = "A novel [ 18F]FRP-170 injection for imaging hypoxia by PET was developed for clinical use. The preparation was based on the simple on-column basic-hydrolysis and the whole procedure was automated by detecting He flow change for transferring and evaporating liquids. [ 18F]FRP-170 was prepared in around 15-20% decay-corrected radiochemical yield within 60 min and stable in saline for more than 6 hr. Radiochemical purity was over 99% and specific activity at EOS was 40-60 GBq/μmol. The radiation-absorbed dose to the whole body was estimated to be 1.0 mSv/185 MBq. The [ 18F]FRP-170 injection proved to be suitable for clinical use without acute toxicity or mutagenicity.",

keywords = "Automated synthesis, F-18, FRP-170, Hypoxic cell maker, PET radiopharmaceutical",

author = "Yoichi Ishikawa and Yoshihito Funaki and Ren Iwata and Shozo Furumoto and Eiko Nakata and Yukitsuka Kudo and Tomohiro Kaneta and Takashi Hakamatsuka and Yoshihiro Takai and Shogo Yamada",

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T1 - Development of [ 18F]FRP-170 injection for imaging hypoxia by PET

AU - Ishikawa, Yoichi

AU - Funaki, Yoshihito

AU - Iwata, Ren

AU - Furumoto, Shozo

AU - Nakata, Eiko

AU - Kudo, Yukitsuka

AU - Kaneta, Tomohiro

AU - Hakamatsuka, Takashi

AU - Takai, Yoshihiro

AU - Yamada, Shogo

PY - 2005/4/22

Y1 - 2005/4/22

N2 - A novel [ 18F]FRP-170 injection for imaging hypoxia by PET was developed for clinical use. The preparation was based on the simple on-column basic-hydrolysis and the whole procedure was automated by detecting He flow change for transferring and evaporating liquids. [ 18F]FRP-170 was prepared in around 15-20% decay-corrected radiochemical yield within 60 min and stable in saline for more than 6 hr. Radiochemical purity was over 99% and specific activity at EOS was 40-60 GBq/μmol. The radiation-absorbed dose to the whole body was estimated to be 1.0 mSv/185 MBq. The [ 18F]FRP-170 injection proved to be suitable for clinical use without acute toxicity or mutagenicity.

AB - A novel [ 18F]FRP-170 injection for imaging hypoxia by PET was developed for clinical use. The preparation was based on the simple on-column basic-hydrolysis and the whole procedure was automated by detecting He flow change for transferring and evaporating liquids. [ 18F]FRP-170 was prepared in around 15-20% decay-corrected radiochemical yield within 60 min and stable in saline for more than 6 hr. Radiochemical purity was over 99% and specific activity at EOS was 40-60 GBq/μmol. The radiation-absorbed dose to the whole body was estimated to be 1.0 mSv/185 MBq. The [ 18F]FRP-170 injection proved to be suitable for clinical use without acute toxicity or mutagenicity.

KW - Automated synthesis

KW - F-18

KW - FRP-170

KW - Hypoxic cell maker

KW - PET radiopharmaceutical

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ER -

Development of [ ¹⁸F]FRP-170 injection for imaging hypoxia by PET

Abstract

Keywords

ASJC Scopus subject areas

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