Development of [ 18F]FRP-170 injection for imaging hypoxia by PET

Yoichi Ishikawa; Yoshihito Funaki; Ren Iwata; Shozo Furumoto; Eiko Nakata; Yukitsuka Kudo; Tomohiro Kaneta; Takashi Hakamatsuka; Yoshihiro Takai; Shogo Yamada

Development of [ ¹⁸F]FRP-170 injection for imaging hypoxia by PET

Yoichi Ishikawa, Yoshihito Funaki, Ren Iwata, Shozo Furumoto, Eiko Nakata, Yukitsuka Kudo, Tomohiro Kaneta, Takashi Hakamatsuka, Yoshihiro Takai, Shogo Yamada

Cyclotron and Radioisotope Center (CYRIC)

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

A novel [ ¹⁸F]FRP-170 injection for imaging hypoxia by PET was developed for clinical use. The preparation was based on the simple on-column basic-hydrolysis and the whole procedure was automated by detecting He flow change for transferring and evaporating liquids. [ ¹⁸F]FRP-170 was prepared in around 15-20% decay-corrected radiochemical yield within 60 min and stable in saline for more than 6 hr. Radiochemical purity was over 99% and specific activity at EOS was 40-60 GBq/μmol. The radiation-absorbed dose to the whole body was estimated to be 1.0 mSv/185 MBq. The [ ¹⁸F]FRP-170 injection proved to be suitable for clinical use without acute toxicity or mutagenicity.

Original language	English
Pages (from-to)	1-10
Number of pages	10
Journal	Kakuigaku
Volume	42
Issue number	1
Publication status	Published - 2005 Apr 22

Keywords

Automated synthesis
F-18
FRP-170
Hypoxic cell maker
PET radiopharmaceutical

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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title = "Development of [ 18F]FRP-170 injection for imaging hypoxia by PET",

abstract = "A novel [ 18F]FRP-170 injection for imaging hypoxia by PET was developed for clinical use. The preparation was based on the simple on-column basic-hydrolysis and the whole procedure was automated by detecting He flow change for transferring and evaporating liquids. [ 18F]FRP-170 was prepared in around 15-20% decay-corrected radiochemical yield within 60 min and stable in saline for more than 6 hr. Radiochemical purity was over 99% and specific activity at EOS was 40-60 GBq/μmol. The radiation-absorbed dose to the whole body was estimated to be 1.0 mSv/185 MBq. The [ 18F]FRP-170 injection proved to be suitable for clinical use without acute toxicity or mutagenicity.",

keywords = "Automated synthesis, F-18, FRP-170, Hypoxic cell maker, PET radiopharmaceutical",

author = "Yoichi Ishikawa and Yoshihito Funaki and Ren Iwata and Shozo Furumoto and Eiko Nakata and Yukitsuka Kudo and Tomohiro Kaneta and Takashi Hakamatsuka and Yoshihiro Takai and Shogo Yamada",

year = "2005",

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T1 - Development of [ 18F]FRP-170 injection for imaging hypoxia by PET

AU - Ishikawa, Yoichi

AU - Funaki, Yoshihito

AU - Iwata, Ren

AU - Furumoto, Shozo

AU - Nakata, Eiko

AU - Kudo, Yukitsuka

AU - Kaneta, Tomohiro

AU - Hakamatsuka, Takashi

AU - Takai, Yoshihiro

AU - Yamada, Shogo

PY - 2005/4/22

Y1 - 2005/4/22

N2 - A novel [ 18F]FRP-170 injection for imaging hypoxia by PET was developed for clinical use. The preparation was based on the simple on-column basic-hydrolysis and the whole procedure was automated by detecting He flow change for transferring and evaporating liquids. [ 18F]FRP-170 was prepared in around 15-20% decay-corrected radiochemical yield within 60 min and stable in saline for more than 6 hr. Radiochemical purity was over 99% and specific activity at EOS was 40-60 GBq/μmol. The radiation-absorbed dose to the whole body was estimated to be 1.0 mSv/185 MBq. The [ 18F]FRP-170 injection proved to be suitable for clinical use without acute toxicity or mutagenicity.

AB - A novel [ 18F]FRP-170 injection for imaging hypoxia by PET was developed for clinical use. The preparation was based on the simple on-column basic-hydrolysis and the whole procedure was automated by detecting He flow change for transferring and evaporating liquids. [ 18F]FRP-170 was prepared in around 15-20% decay-corrected radiochemical yield within 60 min and stable in saline for more than 6 hr. Radiochemical purity was over 99% and specific activity at EOS was 40-60 GBq/μmol. The radiation-absorbed dose to the whole body was estimated to be 1.0 mSv/185 MBq. The [ 18F]FRP-170 injection proved to be suitable for clinical use without acute toxicity or mutagenicity.

KW - Automated synthesis

KW - F-18

KW - FRP-170

KW - Hypoxic cell maker

KW - PET radiopharmaceutical

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