Abstract
A novel [ 18F]FRP-170 injection for imaging hypoxia by PET was developed for clinical use. The preparation was based on the simple on-column basic-hydrolysis and the whole procedure was automated by detecting He flow change for transferring and evaporating liquids. [ 18F]FRP-170 was prepared in around 15-20% decay-corrected radiochemical yield within 60 min and stable in saline for more than 6 hr. Radiochemical purity was over 99% and specific activity at EOS was 40-60 GBq/μmol. The radiation-absorbed dose to the whole body was estimated to be 1.0 mSv/185 MBq. The [ 18F]FRP-170 injection proved to be suitable for clinical use without acute toxicity or mutagenicity.
Original language | English |
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Pages (from-to) | 1-10 |
Number of pages | 10 |
Journal | Kakuigaku |
Volume | 42 |
Issue number | 1 |
Publication status | Published - 2005 Apr 22 |
Keywords
- Automated synthesis
- F-18
- FRP-170
- Hypoxic cell maker
- PET radiopharmaceutical
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging