Development of Si neural probe module with adjustable gain amplifier for neuronal signal recording

Takaharu Tani, Hideki Naganuma, Takuya Harashima, Takuma Iwagami, Hisashi Kino, Koji Kiyoyama, Minna Kellomäki, Jari Hyttinen, Tetsu Tanaka

Research output: Contribution to journalArticlepeer-review


In recent years, lots of research on biomedical technologies directly using bio-signals such as BMI (Brain Machine Interface) have been performed intensively. Among bio-signals, ECoG (Electrocorticogram), LFP (Local Field Potential), and AP (Action Potential) are usually recorded especially for diagnosis, treatment, and prevention of brain diseases. These bio-signals have different amplitudes and frequency bandwidths, and the signal intensities vary accordingly with recording electrode conditions and individual variation. Therefore, a multiple bio-signals recording system having adjustable gain and bandwidth is strongly required. In this study, we designed the adjustable gain amplifier appropriate for the system, and fabricated the module composed of the amplifier and a Si neural probe for the multiple bio-signal recording in the deep brain. Additionally, we verified fundamental functions of the module by in vitro experiments.

Original languageEnglish
Pages (from-to)O-377-O-378
JournalTransactions of Japanese Society for Medical and Biological Engineering
Publication statusPublished - 2014 Aug 17


  • Adjustable gain amplifier
  • Multiple bio-signal recording
  • Si neural probe

ASJC Scopus subject areas

  • Biomedical Engineering


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