Deposition and injection of a small amount material are important techniques for various fields. In particular, in biological fields, it is important to deposit the materials in liquid condition. Atomic force microscope (AFM) can also be used for the local deposition of materials on surface . However, conventional AFM tip is not satisfactory for the deposition in a liquid because of the diffusion of the materials. In the recent years, a glass nanopipette, which has an aperture with nanometer-scale diameter, has been employed as a functional probe of SPMs since the nanopipette can be filled with various kinds of liquid solution inside . Scanning ion-conductance microscope (SICM) is known as a kind of SPM with a nanopipette probe . SICM uses the ionic-conductance field at the edge of the nanopipette to control the probesurface distance. SICM has also been applied for the deposition of the biological materials . However, in depositions using SICM, the deposited material is diffused in the liquid because of the gap of several tens nanometer between the probe edge and the surface. Therefore, the diameter of the deposited dots is much larger than that of the nanopipette aperture . To realize the aperture-size deposition domains, it is necessary to reduce the probe-surface distance during the deposition. However, it is difficult for the nanopipette probe to apply an optical lever method because the nanopipette is long and straight shape. Therefore, it is necessary to develop a selfsensing probe which includes a sensor for detection of the probe displacement. In this paper, we introduce a self-sensing probe with the nanopipette for the AFM observation in the liquid. In order to control the distance between the probe edge and the surface in liquid condition, the nanopipette is employed as a high aspect ratio shape probe. As a performance of the developed self-sensing AFM probe, topographical image was obtained in liquid condition.