Development of self-expandable covered stents

Sachiko Sato, Yasuhide Nakayama, Yoshihiro Miura, Yoshihiro Okamoto, Hiroyuki Asano, Hatsue Ishibashi-Ueda, Yue Min Zhou, Kyoko Hayashida, Toshio Matsuhashi, Kazumasa Seiji, Akihiro Sato, Takayuki Yamada, Shoki Takahashi, Tadashi Ishibashi

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

We newly developed self-expandable covered stents by combining two of our original technologies. Of these, the first is the dip-coating covering method that was developed previously for balloon-expandable stents; the other is the newly developed self-expandable Nitinol stents, namely, Sendai stents. The three types of covered stents with the expansion diameter of 4.5, 5.0, or 6.0 mm thus obtained had a laser-processed microporous elastomeric cover film (pore diameter: 100 μm, interpore distance: 250 μm). Although the film was extremely thin (∼15 μm), the film could be expanded without causing any damage, the strut was completely embedded within the film, and the luminal surface of the film was smooth and flat. Mechanical properties such as ideal flexibility to follow the shapes of arteries were almost retained even after covering. As appropriate drugs, the blood-contacting inner and tissue-contacting outer surfaces of the film were differentially coated with argatroban for antithrombogenicity or FK506 for anti-inflammation, respectively. The preliminary in vivo study indicated that the covered stents mounted in the delivery catheter were navigated and placed to appropriate position in the arteries, and permissible neointimal thickening after 1-month implantation was observed similarly in noncovered stents.

Original languageEnglish
Pages (from-to)345-353
Number of pages9
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume83
Issue number2
DOIs
Publication statusPublished - 2007 Nov

Keywords

  • Covered stents
  • Drug-eluting
  • Self-expandable
  • Sendai stents

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

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