Development of polymeric drug delivery system for recognizing vascular endothelial dysfunction

Kenjiro Ikuta, Takeshi Mori, Tatsurhiro Yamamoto, Takuro Niidome, Hiroaki Shimokawa, Yoshiki Katayama

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

The vascular endothelium plays an important role in regulating vascular homeostasis. Damage to the endothelium can lead to cardiovascular diseases such as arteriosclerosis. Therefore, early-stage detection and evaluation of vascular endothelium dysfunction would be very important for effective diagnosis and therapy. We synthesized a polymeric drug carrier bearing an Evans blue analogue as a probing unit for endothelium injury. The polymeric carrier spontaneously formed stable nanoparticles with micelle-like structure in aqueous media and could encapsulate hydrophobic doxorubicin (DOX). The encapsulated DOX showed a sustainable release profile over a period of 10-60 h depending on the loaded DOX concentration. The polymeric carrier specifically adsorbed against the endothelium-injured site in extracted porcine aorta. These properties of the polymeric drug carrier will be suitable for specific drug delivery to endothelium dysfunctional region.

Original languageEnglish
Pages (from-to)2811-2818
Number of pages8
JournalBioorganic and Medicinal Chemistry
Volume16
Issue number6
DOIs
Publication statusPublished - 2008 Mar 15

Keywords

  • Arteriosclerosis
  • Drug delivery systems
  • Endothelium dysfunction
  • Evans blue analogue

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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