Development of organocatalysis based on the molecular design of pyrrolidine-Brønsted acid catalysts

Susumu Saito, Norie Momiyama, Hisashi Yamamoto

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Proper design of amine-Bransted acid catalysis has been shown to be effective for achieving high reactivity and selectivity in the asymmetric direct aldol reaction. During the course of this study, two principal approaches have been implemented to create a new type of catalysis: One is derived from Brønsted acid and diamine; the other is pyrrolidine with tetrazole functionality. The developed amine-Brønsted acid catalysts have been found to effectively catalyze the direct aldol reaction of aldehyde, chloral and nitrosobenzene.

Original languageEnglish
Pages (from-to)774-784
Number of pages11
JournalYuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
Volume66
Issue number8
DOIs
Publication statusPublished - 2008 Aug

Keywords

  • Asymmetric synthesis
  • Direct aldol reaction
  • Hydrogen bonding
  • Pyrrolidine-Brønsted acid

ASJC Scopus subject areas

  • Organic Chemistry

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