Development of non-invasive regenerative therapy for cardiovascular diseases: Low-energy extracorporeal shock wave therapy

Kenta Ito, Tomohiko Shindo, Tsuyoshi Ogata, Kazuaki Hatanaka, Fukashi Serizawa, Keiichiro Kawamura, Jun Takahashi, Yasuharu Matsumoto, Ryuji Tsuburaya, Kiyotaka Hao, Kensuke Nishimiya, Taro Nihei, Yuji Odaka, Kenichiro Hanawa, Yuhi Hasebe, Hironori Uzuka, Michinori Hirano, Hitoshi Goto, Hiroaki Shimokawa

Research output: Contribution to journalArticlepeer-review

Abstract

We have reported that low-energy extracorporeal shock wave (SW) therapy improves cardiac function in a pig model of chronic myocardial ischemia by up-regulating vascular endothelial growth factor and enhancing angiogenesis. We have also conducted a series of clinical studies in patients with refractory angina pectoris without indication of PCI or CABG. Low-energy SWs were applied from the body surface to ischemic myocardium. In the first open study, the SW therapy significantly improved symptoms and myocardial perfusion. In the second double-blind and placebo-controlled study, symptoms and cardiac function were significantly improved by the SW therapy but not by placebo therapy. No adverse effects were noted. We also demonstrated that the SW therapy significantly improved symptoms, walking ability, and peripheral perfusion in patients with peripheral arterial disease and intermittent claudication. These results suggest that the low-energy SW therapy is promising, non-invasive and effective regenerative option for wide a range of cardiovascular disorders.

Original languageEnglish
Pages (from-to)O-68-O-69
JournalTransactions of Japanese Society for Medical and Biological Engineering
Volume52
DOIs
Publication statusPublished - 2014 Aug 17

Keywords

  • Angina pectoris
  • Angiogenesis
  • Peripheral arterial disease
  • Regeneration
  • Shock wave therapy

ASJC Scopus subject areas

  • Biomedical Engineering

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