Development of madelung-type indole synthesis using copper-catalyzed amidation/condensation strategy

Masahiro Abe; Charline Denneval; Kanako Nozawa-Kumada; Yoshinori Kondo

doi:10.3987/COM-16-13440

Development of madelung-type indole synthesis using copper-catalyzed amidation/condensation strategy

Masahiro Abe, Charline Denneval, Kanako Nozawa-Kumada, Yoshinori Kondo

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

Abstract

A new method for Madelung-type indole synthesis was investigated, and it was found that the amidation of 2-iodophenylacetonitrile with various alkanamides proceeds smoothly in the presence of CuI and a diamine ligand. The subsequent cyclization of the C-N coupling products takes place under the coupling reaction conditions.

Original language	English
Pages (from-to)	900-909
Number of pages	10
Journal	Heterocycles
Volume	92
Issue number	5
DOIs	https://doi.org/10.3987/COM-16-13440
Publication status	Published - 2016

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

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10.3987/COM-16-13440

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title = "Development of madelung-type indole synthesis using copper-catalyzed amidation/condensation strategy",

abstract = "A new method for Madelung-type indole synthesis was investigated, and it was found that the amidation of 2-iodophenylacetonitrile with various alkanamides proceeds smoothly in the presence of CuI and a diamine ligand. The subsequent cyclization of the C-N coupling products takes place under the coupling reaction conditions.",

author = "Masahiro Abe and Charline Denneval and Kanako Nozawa-Kumada and Yoshinori Kondo",

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AU - Kondo, Yoshinori

PY - 2016

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AB - A new method for Madelung-type indole synthesis was investigated, and it was found that the amidation of 2-iodophenylacetonitrile with various alkanamides proceeds smoothly in the presence of CuI and a diamine ligand. The subsequent cyclization of the C-N coupling products takes place under the coupling reaction conditions.

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Development of madelung-type indole synthesis using copper-catalyzed amidation/condensation strategy

Abstract

ASJC Scopus subject areas

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