Development of madelung-type indole synthesis using copper-catalyzed amidation/condensation strategy

Masahiro Abe, Charline Denneval, Kanako Nozawa-Kumada, Yoshinori Kondo

Research output: Contribution to journalArticlepeer-review

Abstract

A new method for Madelung-type indole synthesis was investigated, and it was found that the amidation of 2-iodophenylacetonitrile with various alkanamides proceeds smoothly in the presence of CuI and a diamine ligand. The subsequent cyclization of the C-N coupling products takes place under the coupling reaction conditions.

Original languageEnglish
Pages (from-to)900-909
Number of pages10
JournalHeterocycles
Volume92
Issue number5
DOIs
Publication statusPublished - 2016

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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