Development of label-free bioaffinity sensor using a lumped-constant microwave resonator probe

Noriaki Okazaki, Taito Nishino, Toyohiro Chikyow, Yasuo Cho

Research output: Contribution to journalArticlepeer-review

Abstract

A novel label-free bioaffinity sensor using a lumped-constant microwave resonator was developed. A gold probe with a spherical tip immobilizing anti-chicken egg albumin antibody or anti-human albumin antibody on its surface was connected to the resonator and inserted into a flow cell to monitor the target antigen binding. The sensor showed specific sensitivity against its target antigen evidenced by the change of resonance frequency after the antigen injection. The large frequency shift observed during the injection of antigen solution was ascribed to the change of solution dielectric constant which showed a systematic increase with antigen concentration.

Original languageEnglish
Article number017001
JournalApplied Physics Express
Volume4
Issue number1
DOIs
Publication statusPublished - 2011 Jan 1

ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy(all)

Fingerprint Dive into the research topics of 'Development of label-free bioaffinity sensor using a lumped-constant microwave resonator probe'. Together they form a unique fingerprint.

Cite this