Development of intracoronary local adhesive delivery technique

T. Sonobe, S. Naganuma, T. Yambe, S. I. Kobayashi, K. Sizuka, Y. Katahira, K. Nitta, S. I. Nitta

Research output: Contribution to journalArticle

Abstract

Acute coronary occlusion may occur in weak coronary atherosclerotic lesions, including dissection, ulceration or thrombus. In some cases of occlusion 'bail-out' is performed by using recently developed New Devices. However, these have not yet completely solved the problem to this end, we designed a new method of coronary revascularization, the Intracoronary Local Adhesive Delivery Technique, utilizing antithrombotic and absorbable adhesive injected locally into the fragile and morbid arterial wall using a drug delivery PTCA catheter more flexible than the existing New Devices. This adhesive strengthened and hardened the lesions. In this study we examined the efficacy of making an adhesive cylinder in arteries of similar size to the coronary through acute animal experiments using the existing clinical adhesives and drug delivery PTCA catheters and 12 femoral arteries of adult goats. We were successful in forming firm tunnels along the inside of six arteries, infused with approximately 0.04 ml Cyanoacrylate. These tunnels were observed with intravascular ultrasound (IVUS) imaging and evaluated microscopically These results suggest the feasibility of this method as a new approach for making synthetic resinous stents.

Original languageEnglish
Pages (from-to)319-326
Number of pages8
JournalInternational Journal of Artificial Organs
Volume20
Issue number6
Publication statusPublished - 1997 Jun 1
Externally publishedYes

Keywords

  • Acute coronary occlusion
  • Adhesive
  • Cyanoacrylate
  • Drug delivery PTCA catheter
  • Resinous stent

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

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  • Cite this

    Sonobe, T., Naganuma, S., Yambe, T., Kobayashi, S. I., Sizuka, K., Katahira, Y., Nitta, K., & Nitta, S. I. (1997). Development of intracoronary local adhesive delivery technique. International Journal of Artificial Organs, 20(6), 319-326.