Development of functional molecules with biological molecular machines: Control of chaperonin functions by introduction of photoresponsive units

Shinichi Muramatsu, Kazushi Kinbara, Takuzo Aida, Hideki Taguchi, Masasuke Yoshida

Research output: Contribution to conferencePaperpeer-review

Abstract

Chaperonin GroEL, one of the molecular chaperones, is a cylindrical protein consisting of 14 identical subunits. GroEL works as a molecular machine driven by ATP. Photoresponsive units, azobenzene derivatives, which undergo trans to cis isomerization upon exposure to UV and visible light, were attached to GroEL in order to control the protein function by light energy. The refolding rate of guest protein trapped by the modified GroEL could be controlled by photoirradiation.

Original languageEnglish
Pages4961-4962
Number of pages2
Publication statusPublished - 2005 Dec 1
Event54th SPSJ Symposium on Macromolecules - Yamagata, Japan
Duration: 2005 Sep 202005 Sep 22

Other

Other54th SPSJ Symposium on Macromolecules
CountryJapan
CityYamagata
Period05/9/2005/9/22

Keywords

  • Azobenzene
  • Chaperonin
  • Photo-control

ASJC Scopus subject areas

  • Engineering(all)

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